Link between endoplasmic reticulum stress and autophagy in neurodegenerative diseases
Abstract: Increasing evidence suggests that endoplasmic reticulum (ER) stress and autophagy play an important role in regulating brain function. ER stress activates three major branches of the unfolded protein response (UPR) pathways, namely inositol-requiring enzyme-1 (IRE1), double stranded RNA-activated protein kinase (PKR)-like ER kinase (PERK) and activating transcription factor 6 (ATF6)-mediated pathways. Recent studies have suggested that these UPR signals may be linked to autophagy. In this review article, we summarize recent evidence and discuss a possible link between ER stress and autophagy with regard to neurodegenerative diseases. Furthermore, possible pharmacological strategies targeting UPR and autophagy are discussed.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Link between endoplasmic reticulum stress and autophagy in neurodegenerative diseases ; volume:4 ; number:1 ; year:2017 ; pages:37-45 ; extent:9
Endoplasmic reticulum stress in diseases ; 4, Heft 1 (2017), 37-45 (gesamt 9)
- Creator
-
Hosoi, Toru
Nomura, Jun
Tanaka, Keigo
Ozawa, Koichiro
Nishi, Akinori
Nomura, Yasuyuki
- DOI
-
10.1515/ersc-2017-0004
- URN
-
urn:nbn:de:101:1-2412170920028.961265087377
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 15.08.2025, 7:33 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hosoi, Toru
- Nomura, Jun
- Tanaka, Keigo
- Ozawa, Koichiro
- Nishi, Akinori
- Nomura, Yasuyuki
Other Objects (12)
Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases
Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer
Endoplasmic reticulum stress in diseases
Endoplasmic Reticulum Stress and Allergic Diseases
ER ‐phagy: selective autophagy of the endoplasmic reticulum
Excess diacylglycerol at the endoplasmic reticulum disrupts endomembrane homeostasis and autophagy
The plant endoplasmic reticulum
Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy
Autophagy and Endoplasmic Reticulum Stress during Onset and Progression of Arrhythmogenic Cardiomyopathy
On the role of endoplasmic reticulum homeostasis and autophagy in intestinal inflammation
Structure of the endoplasmic reticulum
Endoplasmic reticulum dynamics in mitosis
Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases
Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer
Endoplasmic reticulum stress in diseases
Endoplasmic Reticulum Stress and Allergic Diseases
ER ‐phagy: selective autophagy of the endoplasmic reticulum
Excess diacylglycerol at the endoplasmic reticulum disrupts endomembrane homeostasis and autophagy
The plant endoplasmic reticulum
Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy
Autophagy and Endoplasmic Reticulum Stress during Onset and Progression of Arrhythmogenic Cardiomyopathy
On the role of endoplasmic reticulum homeostasis and autophagy in intestinal inflammation
Structure of the endoplasmic reticulum
Endoplasmic reticulum dynamics in mitosis
Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases
Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer
Endoplasmic reticulum stress in diseases
Endoplasmic Reticulum Stress and Allergic Diseases
ER ‐phagy: selective autophagy of the endoplasmic reticulum
Excess diacylglycerol at the endoplasmic reticulum disrupts endomembrane homeostasis and autophagy
The plant endoplasmic reticulum
Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy
Autophagy and Endoplasmic Reticulum Stress during Onset and Progression of Arrhythmogenic Cardiomyopathy
On the role of endoplasmic reticulum homeostasis and autophagy in intestinal inflammation
Structure of the endoplasmic reticulum