Spirocyclic Chromenopyrazole Inhibitors Disrupting the Interaction between the RNA‐Binding Protein LIN28 and Let‐7
Abstract: Small‐molecule inhibitors of the RNA‐binding and regulating protein LIN28 have the potential to be developed as chemical probes for biological perturbation and as therapeutic candidates. Reported small molecules disrupting the interaction between LIN28 and let‐7 miRNA suffer from moderate to weak inhibitory activity and flat structure‐activity relationship, which hindered the development of next‐generation LIN28 inhibitors that warrant further evaluations. We report herein the identification of new LIN28 inhibitors utilizing a spirocyclization strategy based on a chromenopyrazole scaffold. Representative compounds 2–5 showed potent in vitro inhibitory activity against LIN28‐let‐7 interaction and single‐digit micromolar potency in inhibiting the proliferation of LIN28‐expressing JAR cancer cells. The spirocyclic compound 5 incorporated a position that is amenable for functional group appendage and further structural modifications. The binding mode of compound 5 with the LIN28 cold shock domain was rationalized via a molecular docking analysis.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Spirocyclic Chromenopyrazole Inhibitors Disrupting the Interaction between the RNA‐Binding Protein LIN28 and Let‐7 ; day:31 ; month:07 ; year:2023 ; extent:9
ChemBioChem ; (31.07.2023) (gesamt 9)
- Creator
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Borgelt, Lydia
Huang, Fubao
Hohnen, Lisa
Qiu, Xiaqiu
Goebel, Georg L.
Hommen, Pascal
Wu, Peng
- DOI
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10.1002/cbic.202300168
- URN
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urn:nbn:de:101:1-2023073115165398102216
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 14.08.2025, 10:50 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Borgelt, Lydia
- Huang, Fubao
- Hohnen, Lisa
- Qiu, Xiaqiu
- Goebel, Georg L.
- Hommen, Pascal
- Wu, Peng
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