DNA sequence-selective monoheterocyclic analog of Hoechst 33258: cytotoxicity and antiparasitic properties

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Abstract: The biophysical and biological evaluations of DNA minor groove binding AT sequence selective benzimidazole analogs of Hoechst 33258 which contain a p-anisyl, a p-[bis (2-chloroethyl) amino]phenyl or a p-anisyl and an amidine moiety are discussed. The preference for all three compounds for the 5′-AAATTT-3′ sequence was ascertained by thermal denaturation and circular dichroism studies. The mustard-containing compound 4 was found to be more cytotoxic against murine cancer cells grown in culture than the non-mustard containing compound. DNA alkylation was not necessary for anti-Leishmanial activity.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
DNA sequence-selective monoheterocyclic analog of Hoechst 33258: cytotoxicity and antiparasitic properties ; volume:16 ; number:4-6 ; year:2010 ; pages:227-230
Heterocyclic communications ; 16, Heft 4-6 (2010), 227-230

Creator
Chavda, Sameer
Dittenhafer, Kristen
Wu, Kristy
Merrick, Curtis
Desta, Dereje
Cordes, Emily
Babu, Balaji
Tzou, Samuel
Brockway, Olivia
Sjoholm, Robert
Lee, Moses

DOI
10.1515/HC.2010.004
URN
urn:nbn:de:101:1-2501130527579.600508319351
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:29 AM CEST

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Associated

  • Chavda, Sameer
  • Dittenhafer, Kristen
  • Wu, Kristy
  • Merrick, Curtis
  • Desta, Dereje
  • Cordes, Emily
  • Babu, Balaji
  • Tzou, Samuel
  • Brockway, Olivia
  • Sjoholm, Robert
  • Lee, Moses

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