Proton‐Gradient‐Driven Sensitivity Enhancement of Liposome‐Encapsulated Supramolecular Chemosensors
Abstract: An overarching challenge in the development of supramolecular sensor systems is to enhance their sensitivity, which commonly involves the synthesis of refined receptors with increased affinity to the analyte. We show that a dramatic sensitivity increase by 1–2 orders of magnitude can be achieved by encapsulating supramolecular chemosensors inside liposomes and exposing them to a pH gradient across the lipid bilayer membrane. This causes an imbalance of the influx and efflux rates of basic and acidic analytes leading to a significantly increased concentration of the analyte in the liposome interior. The utility of our liposome‐enhanced sensors was demonstrated with various host–dye reporter pairs and sensing mechanisms, and we could easily increase the sensitivity towards multiple biologically relevant analytes, including the neurotransmitters serotonin and tryptamine.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Proton‐Gradient‐Driven Sensitivity Enhancement of Liposome‐Encapsulated Supramolecular Chemosensors ; day:13 ; month:07 ; year:2022 ; extent:1
Angewandte Chemie / International edition. International edition ; (13.07.2022) (gesamt 1)
- Creator
- DOI
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10.1002/anie.202207950
- URN
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urn:nbn:de:101:1-2022071415100036141215
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 15.08.2025, 7:22 AM CEST
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Associated
- Nilam, Mohamed
- Karmacharya, Shreya
- Nau, Werner
- Hennig, Andreas
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Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply
In vivo and in vitro toxicity evaluation of liposome-encapsulated sirolimus
Study on intracellular delivery of liposome encapsulated quantum dots using advanced fluorescence microscopy
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Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells
Evaluation of the immunogenicity of liposome encapsulated HVR1 and NS3 regions of genotype 3 HCV, either singly or in combination
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Enhancement of cisplatin sensitivity in lewis lung carcinoma by liposome-mediated delivery of a survivin mutant