Correlation of preoperative sonographic staging and postoperative histopathologic staging in patients with invasive breast cancer

Abstract: Purpose
To assess the accuracy of preoperative sonographic staging in patients with primary invasive breast cancer.

Methods
We retrospectively analyzed a prospectively kept service database of patients with newly diagnosed, unifocal, cT1-3, invasive breast cancer. All patients were diagnosed at a single center institution between January 2013 and December 2021. Clinical T stage was assessed preoperatively by ultrasound and correlated with the definite postoperative pathologic T stage. Demographics, clinical and pathological characteristics were collected. Factors influencing accuracy, over- and underdiagnosis of sonographic staging were analyzed with multivariable regression analysis.

Results
A total of 2478 patients were included in the analysis. Median patients’ age was 65 years. 1577 patients (63.6%) had clinical T1 stage, 864 (34.9%) T2 and 37 (1.5%) T3 stage. The overall accuracy of sonography and histology was 76.5% (n = 1896), overestimation was observed in 9.1% (n = 225) of all cases, while underestimation occurred in 14.4% (n = 357) of all cases. Accuracy increased when clinical tumor stage cT was higher (OR 1.23; 95% CI 1.10–1.38, p ≤ 0.001). The highest accuracy was seen for patients with T2 stage (82.8%). The accuracy was lower in Luminal B tumors compared to Luminal A tumors (OR 0.71; 95% CI 0.59–0.87, p ≤ 0.001). We could not find any association between sonographic accuracy in HER2 positive patients, and demographic characteristics, or tumor-related factors.

Conclusion
Our unicentric study showed a high accuracy of sonography in predicting T stage, especially for tumors with clinical T2 stage. Tumor stage and biological tumor factors do affect the accuracy of sonographic staging

Objekt anzeigen

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Archives of gynecology and obstetrics. - 310, 5 (2024) , 2623-2630, ISSN: 1432-0711

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2024
• Urheber: Müller, Carolin ; Zimmermann, Julia S. M. ; Radosa, Marc Philipp ; Hahn, Anna Katharina ; Kaya, Askin Cangül ; Huwer, Sarah ; Stotz, Lisa ; Wagenpfeil, Gudrun ; Radosa, Christoph Georg ; Solomayer, Erich-Franz ; Radosa, Julia Caroline

Weitere Informationen

• DOI: 10.1007/s00404-024-07699-5
• URN: urn:nbn:de:bsz:25-freidok-2573823
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.