Journal article | Zeitschriftenartikel
Child and adolescent psychiatric genetics
The current status of child and adolescent psychiatric genetics appears promising in light of the initiation of genome-wide association studies (GWAS) for diverse polygenic disorders and the molecular elucidation of monogenic Rett syndrome, for which recent functional studies provide hope for pharmacological treatment strategies. Within the last 50 years, tremendous progress has been made in linking genetic variation to behavioral phenotypes and psychiatric disorders. We summarize the major findings of the Human Genome Project and dwell on largely unsuccessful candidate gene and linkage studies. GWAS for the first time offer the possibility to detect single nucleotide polymorphisms and copy number variants without a priori hypotheses as to their molecular etiology. At the same time it is becoming increasingly clear that very large sample sizes are required in order to enable genome wide significant findings, thus necessitating further large-scaled ascertainment schemes for the successful elucidation of the molecular genetics of childhood and adolescent psychiatric disorders. We conclude by reflecting on different scenarios for future research into the molecular basis of early onset psychiatric disorders. This review represents the introductory article of this special issue of the European Child and Adolescent Psychiatry.
- Umfang
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Seite(n): 259-279
- Anmerkungen
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Status: Postprint; begutachtet (peer reviewed)
- Erschienen in
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European Child & Adolescent Psychiatry, 19(3)
- Thema
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Medizin und Gesundheit
Medizin, Sozialmedizin
- Ereignis
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Geistige Schöpfung
- (wer)
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Hebebrand, Johannes
Scherag, Andre
Schimmelmann, Benno G.
Hinney, Anke
- Ereignis
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Veröffentlichung
- (wo)
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Deutschland
- (wann)
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2010
- DOI
- URN
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urn:nbn:de:0168-ssoar-215630
- Rechteinformation
-
GESIS - Leibniz-Institut für Sozialwissenschaften. Bibliothek Köln
- Letzte Aktualisierung
-
21.06.2024, 16:26 MESZ
Datenpartner
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Objekttyp
- Zeitschriftenartikel
Beteiligte
- Hebebrand, Johannes
- Scherag, Andre
- Schimmelmann, Benno G.
- Hinney, Anke
Entstanden
- 2010
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