Homology modeling of 3D structure of human chitinase-like protein CHI3L2
Abstract: The human genome encodes six proteins of family 18 glycosyl hydrolases, two active chitinases and four chitinase-like lectins (chi-lectins) lacking catalytic activity. The present article is dedicated to homology modeling of 3D structure of human chitinase 3-like 2 protein (CHI3L2), which is overexpressed in glial brain tumors, and its structural comparison with homologous chi-lectin CHI3L1. Two crystal structures of CHI3L1 in free state (Protein Data Bank codes 1HJX and 1NWR) were used as structural templates for the homology modeling by Modeller 9.7 program, and the best quality model structure was selected from the obtained model ensemble. Analysis of potential oligosaccharide-binding groove structures of CHI3L1 and CHI3L2 revealed significant differences between these two homologous proteins. 8 of 19 amino acid residues important for ligand binding are substituted in CHI3L2: Tyr34/Asp39, Trp69/Lys74, Trp71/Lys76, Trp99/Tyr104, Asn100/Leu105, Met204/Leu210, Tyr206/Phe212 and Arg263/His271. The differences between these residues could influence the structure of the ligand-binding groove and substantially change the ability of CHI3L2 to bind oligosaccharide ligands.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Homology modeling of 3D structure of human chitinase-like protein CHI3L2 ; volume:5 ; number:4 ; year:2010 ; pages:407-420 ; extent:14
Open life sciences ; 5, Heft 4 (2010), 407-420 (gesamt 14)
- Urheber
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Iershov, Anton
Odynets, Konstantin
Kornelyuk, Alexander
Kavsan, Vadim
- DOI
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10.2478/s11535-010-0039-8
- URN
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urn:nbn:de:101:1-2409201835546.013208822702
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:37 MESZ
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Beteiligte
- Iershov, Anton
- Odynets, Konstantin
- Kornelyuk, Alexander
- Kavsan, Vadim
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