miR-223-3p and miR-24-3p as novel serum-based biomarkers for myotonic dystrophy type 1

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Abstract: Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy, primarily characterized by muscle wasting and weakness. Many biomarkers already exist in the rapidly developing biomarker research field that aim to improve patients’ care. Limited work, however, has been performed on rare diseases, including DM1. We have previously shown that specific microRNAs (miRNAs) can be used as potential biomarkers for DM1 progression. In this report, we aimed to identify novel serum-based biomarkers for DM1 through high-throughput next-generation sequencing. A number of miRNAs were identified that are able to distinguish DM1 patients from healthy individuals. Two miRNAs were selected, and their association with the disease was validated in a larger panel of patients. Further investigation of miR-223-3p, miR-24-3p, and the four previously identified miRNAs, miR-1-3p, miR-133a-3p, miR-133b-3p, and miR-206-3p, showed elevated levels in a DM1 mouse model for all six miRNAs circulating in the serum compared to healthy controls. Importantly, the levels of miR-223-3p, but not the other five miRNAs, were found to be significantly downregulated in five skeletal muscles and heart tissues of DM1 mice compared to controls. This result provides significant evidence for its involvement in disease manifestation

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
Molecular therapy. Methods & clinical development. - 23 (2021) , 169-183, ISSN: 2329-0501

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2021
Creator
Koutalianos, Demetris
Koutsoulidou, Andrie
Mytidou, Chrystalla
Kakouri, Andrea C.
Oulas, Anastasis
Tomazou, Marios
Kyriakides, Tassos C.
Prokopi, Marianna
Kapnisis, Konstantinos
Nikolenko, Nikoletta
Turner, Chris
Lusakowska, Anna
Janiszewska, Katarzyna
Papadimas, George K.
Papadopoulos, Constantinos
Kararizou, Evangelia
Spyrou, George M.
Gourdon, Genevieve
Zamba Papanicolaou, Eleni
Gorman, Grainne
Anayiotos, Andreas
Lochmüller, Hanns
Phylactou, Leonidas A.

DOI
10.1016/j.omtm.2021.09.007
URN
urn:nbn:de:bsz:25-freidok-2226236
Rights
Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:26 AM CEST

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Associated

  • Koutalianos, Demetris
  • Koutsoulidou, Andrie
  • Mytidou, Chrystalla
  • Kakouri, Andrea C.
  • Oulas, Anastasis
  • Tomazou, Marios
  • Kyriakides, Tassos C.
  • Prokopi, Marianna
  • Kapnisis, Konstantinos
  • Nikolenko, Nikoletta
  • Turner, Chris
  • Lusakowska, Anna
  • Janiszewska, Katarzyna
  • Papadimas, George K.
  • Papadopoulos, Constantinos
  • Kararizou, Evangelia
  • Spyrou, George M.
  • Gourdon, Genevieve
  • Zamba Papanicolaou, Eleni
  • Gorman, Grainne
  • Anayiotos, Andreas
  • Lochmüller, Hanns
  • Phylactou, Leonidas A.
  • Universität

Time of origin

  • 2021

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