Plasma medical oncology: Immunological interpretation of head and neck squamous cell carcinoma

Abstract: The prognosis of patients suffering from advanced‐stage head and neck squamous cell carcinoma (HNSCC) remains poor. Medical gas plasma therapy receives growing attention as a novel anticancer modality. Our recent prospective observational study on HNSCC patients suffering from contaminated tumor ulcerations without lasting remission after first‐line anticancer therapy showed remarkable efficacy of gas plasma treatment, with the ulcerated tumor surface decreasing by up to 80%. However, tumor growth relapsed, and this biphasic response may be a consequence of immunological and molecular changes in the tumor microenvironment that could be caused by (a) immunosuppression, (b) tumor cell adaption, (c) loss of microbe‐induced immunostimulation, and/or (d) stromal cell adaption. These considerations may be vital for the design of clinical plasma trials in the future.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Plasma medical oncology: Immunological interpretation of head and neck squamous cell carcinoma ; volume:17 ; number:10 ; year:2020 ; extent:9 ; Plasma processes and polymers ; 17, Heft 10 (2020) (gesamt 9)

Contributors, Places and Time

• Creator: Witzke, Katharina ; Seebauer, Christian ; Jesse, Katja ; Kwiatek, Elisa ; Berner, Julia ; Semmler, Marie‐Luise ; Boeckmann, Lars ; Emmert, Steffen ; Weltmann, Klaus‐Dieter ; Metelmann, Hans‐Robert ; Bekeschus, Sander

Further information

• DOI: 10.1002/ppap.201900258
• URN: urn:nbn:de:101:1-2022070212280513439378
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:21 AM CEST