Working in close quarters: biparental meiosis in the oocyte

In vitro fertilization (IVF) methods involve fertilizing haploid oocytes arrested in meiosis II with haploid sperm. An experimental IVF method had been developed in mice involving injection of diploid sperm nuclei into equally diploid oocytes (biparental meiosis) to increase the chance of reproduction in cases where haploid sperm cannot be obtained. However, this method had been shown to be highly error prone. In this issue of EMBO Reports, Ogonuki et al show that reducing ooplasm volume by half reduces the segregation errors and increases the likelihood of producing viable offsprings in mice (Ogonuki et al, 2022).

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Working in close quarters: biparental meiosis in the oocyte ; day:27 ; month:05 ; year:2022 ; extent:3 ; EMBO reports / European Molecular Biology Organization ; (27.05.2022) (gesamt 3)

Contributors, Places and Time

• Creator: Bouftas, Nora ; Wassmann, Katja

Further information

• DOI: 10.15252/embr.202255360
• URN: urn:nbn:de:101:1-2022052715091572647084
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:31 AM CEST