Artificial Channels in an Infectious Biofilm Created by Magnetic Nanoparticles Enhanced Bacterial Killing by Antibiotics
Abstract: The poor penetrability of many biofilms contributes to the recalcitrance of infectious biofilms to antimicrobial treatment. Here, a new application for the use of magnetic nanoparticles in nanomedicine to create artificial channels in infectious biofilms to enhance antimicrobial penetration and bacterial killing is proposed. Staphylococcus aureus biofilms are exposed to magnetic‐iron‐oxide nanoparticles (MIONPs), while magnetically forcing MIONP movement through the biofilm. Confocal laser scanning microscopy demonstrates artificial channel digging perpendicular to the substratum surface. Artificial channel digging significantly (4–6‐fold) enhances biofilm penetration and bacterial killing efficacy by gentamicin in two S. aureus strains with and without the ability to produce extracellular polymeric substances. Herewith, this work provides a simple, new, and easy way to enhance the eradication of infectious biofilms using MIONPs combined with clinically applied antibiotic therapies.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Artificial Channels in an Infectious Biofilm Created by Magnetic Nanoparticles Enhanced Bacterial Killing by Antibiotics ; volume:15 ; number:39 ; year:2019 ; extent:6
Small ; 15, Heft 39 (2019) (gesamt 6)
- Creator
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Quan, Kecheng
Zhang, Zexin
Chen, Hong
Ren, Xiaoxiang
Ren, Yijin
Peterson, Brandon W.
van der Mei, Henny C.
Busscher, Henk J.
- DOI
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10.1002/smll.201902313
- URN
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urn:nbn:de:101:1-2022073112204002327127
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:31 AM CEST
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Quan, Kecheng
- Zhang, Zexin
- Chen, Hong
- Ren, Xiaoxiang
- Ren, Yijin
- Peterson, Brandon W.
- van der Mei, Henny C.
- Busscher, Henk J.
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