A few good reasons to use nanobodies for cancer treatment
Abstract: mAbs have been instrumental for targeted cancer therapies. However, their relatively large size and physicochemical properties result in a heterogenous distribution in the tumor microenvironment, usually restricted to the first cell layers surrounding blood vessels, and a limited ability to penetrate the brain. Nanobodies are tenfold smaller, resulting in a deeper tumor penetration and the ability to reach cells in poorly perfused tumor areas. Nanobodies are rapidly cleared from the circulation, which generates a fast target‐to‐background contrast that is ideally suited for molecular imaging purposes but may be less optimal for therapy. To circumvent this problem, nanobodies have been formatted to noncovalently bind albumin, increasing their serum half‐life without majorly increasing their size. Finally, nanobodies have shown superior qualities to infiltrate brain tumors as compared to mAbs. In this review, we discuss why these features make nanobodies prime candidates for targeted therapy of cancer.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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A few good reasons to use nanobodies for cancer treatment ; day:27 ; month:06 ; year:2023 ; extent:8
European journal of immunology ; (27.06.2023) (gesamt 8)
- Urheber
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Jumapili, Neema Ahishakiye
Zivalj, Maida
Barthelmess, Romina Mora
Raes, Geert
De Groof, Timo W. M.
Devoogdt, Nick
Stijlemans, Benoît
Vincke, Cécile
Van Ginderachter, Jo A.
- DOI
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10.1002/eji.202250024
- URN
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urn:nbn:de:101:1-2023062715224374993827
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:55 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Jumapili, Neema Ahishakiye
- Zivalj, Maida
- Barthelmess, Romina Mora
- Raes, Geert
- De Groof, Timo W. M.
- Devoogdt, Nick
- Stijlemans, Benoît
- Vincke, Cécile
- Van Ginderachter, Jo A.
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