Contrast-enhanced near-infrared photoacoustic microscopy and optical coherence tomography imaging of rat fundus
Abstract: In this paper, we design a multimodal visible/near-infrared photoacoustic microscopy and optical coherence tomography (VIS/NIR-PAM-OCT) system for imaging both retina and retinal pigment epithelium (RPE)/choroid complex layer. F127 and DSPE-PEG-cRGD encapsulated IR-1048 nanoparticles (FINPs) exhibiting absorption peak up to 1,064 nm were utilized as contrast agents to enhance NIR-PAM for in vivo imaging of fundus tissues. The fundus structure and vessels are clearly visualized by the multimodal imaging, and their parameters were quantitatively analyzed. NIR-PAM and OCT imaging of fundus were time-serially monitored over 60 min following the intravenous injection of FINPs into rats. The results indicated a 134 % increase in image signals in PAM at 1 min, along with an 8.23 % intensity enhancement in OCT. Moreover, laser-induced choroidal neovascularization (CNV) was specifically detected and accurately quantified using VIS/NIR-PAM-OCT. Lastly, FINPs demonstrated excellent biocompatibility in hematology analysis and pathology testing.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Contrast-enhanced near-infrared photoacoustic microscopy and optical coherence tomography imaging of rat fundus ; volume:13 ; number:19 ; year:2024 ; pages:3631-3646 ; extent:16
Nanophotonics ; 13, Heft 19 (2024), 3631-3646 (gesamt 16)
- Urheber
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Du, Fengxian
Niu, Chen
Zeng, Silue
Chen, Jingqin
Liu, Chengbo
Dai, Cuixia
- DOI
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10.1515/nanoph-2023-0872
- URN
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urn:nbn:de:101:1-2408311535174.478680859136
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:27 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Du, Fengxian
- Niu, Chen
- Zeng, Silue
- Chen, Jingqin
- Liu, Chengbo
- Dai, Cuixia
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