T7 Phage as an Emerging Nanobiomaterial with Genetically Tunable Target Specificity
Abstract: Bacteriophages, also known as phages, are specific antagonists against bacteria. T7 phage has drawn massive attention in precision medicine owing to its distinctive advantages, such as short replication cycle, ease in displaying peptides and proteins, high stability and cloning efficiency, facile manipulation, and convenient storage. By introducing foreign gene into phage DNA, T7 phage can present foreign peptides or proteins site‐specifically on its capsid, enabling it to become a nanoparticle that can be genetically engineered to screen and display a peptide or protein capable of recognizing a specific target with high affinity. This review critically introduces the biomedical use of T7 phage, ranging from the detection of serological biomarkers and bacterial pathogens, recognition of cells or tissues with high affinity, design of gene vectors or vaccines, to targeted therapy of different challenging diseases (e.g., bacterial infection, cancer, neurodegenerative disease, inflammatory disease, and foot–mouth disease). It also discusses perspectives and challenges in exploring T7 phage, including the understanding of its interactions with human body, assembly into scaffolds for tissue regeneration, integration with genome editing, and theranostic use in clinics. As a genetically modifiable biological nanoparticle, T7 phage holds promise as biomedical imaging probes, therapeutic agents, drug and gene carriers, and detection tools.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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T7 Phage as an Emerging Nanobiomaterial with Genetically Tunable Target Specificity ; day:16 ; month:12 ; year:2021 ; extent:25
Advanced science ; (16.12.2021) (gesamt 25)
- Creator
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Yue, Hui
Li, Yan
Yang, Mingying
Mao, Chuanbin
- DOI
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10.1002/advs.202103645
- URN
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urn:nbn:de:101:1-2021121714115277294538
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:29 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Yue, Hui
- Li, Yan
- Yang, Mingying
- Mao, Chuanbin
Other Objects (12)
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Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library
Isolation and characterization of a T7-like lytic phage for Pseudomonas fluorescens
T7 phage-assisted evolution of riboswitches using error-prone replication and dual selection
Rapid detection of Escherichia coli in beverages using genetically engineered bacteriophage T7
Bacteriophage biodistribution and infectivity from honeybee to bee larvae using a T7 phage model
Kriegsbibliothek. T.7.
Illustration: T7
Salting‐out extraction of recombinant κ‐carrageenase and phage T7 released from Escherichia coli cells
Prediction of Klebsiella phage-host specificity at the strain level
Editing of Phage Genomes—Recombineering-assisted SpCas9 Modification of Model Coliphages T7, T5, and T3
Genetically Programmed Protein-based Hydrogels with Tunable Mechanical Properties
Versuche T1 - T7
Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library
Isolation and characterization of a T7-like lytic phage for Pseudomonas fluorescens
T7 phage-assisted evolution of riboswitches using error-prone replication and dual selection
Rapid detection of Escherichia coli in beverages using genetically engineered bacteriophage T7
Bacteriophage biodistribution and infectivity from honeybee to bee larvae using a T7 phage model
Kriegsbibliothek. T.7.
Illustration: T7
Salting‐out extraction of recombinant κ‐carrageenase and phage T7 released from Escherichia coli cells
Prediction of Klebsiella phage-host specificity at the strain level
Editing of Phage Genomes—Recombineering-assisted SpCas9 Modification of Model Coliphages T7, T5, and T3
Genetically Programmed Protein-based Hydrogels with Tunable Mechanical Properties