Amide Synthesis by Nickel/Photoredox‐Catalyzed Direct Carbamoylation of (Hetero) Aryl Bromides

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Abstract: Herein, we report a one‐electron strategy for catalytic amide synthesis that enables the direct carbamoylation of (hetero) aryl bromides. This radical cross‐coupling approach, which is based on the combination of nickel and photoredox catalysis, proceeds at ambient temperature and uses readily available dihydropyridines as precursors of carbamoyl radicals. The method's mild reaction conditions make it tolerant of sensitive‐functional‐group‐containing substrates and allow the installation of an amide scaffold within biologically relevant heterocycles. In addition, we installed amide functionalities bearing electron‐poor and sterically hindered amine moieties, which would be difficult to prepare with classical dehydrative condensation methods.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Amide Synthesis by Nickel/Photoredox‐Catalyzed Direct Carbamoylation of (Hetero) Aryl Bromides ; volume:132 ; number:13 ; year:2020 ; pages:5286-5291 ; extent:6
Angewandte Chemie ; 132, Heft 13 (2020), 5286-5291 (gesamt 6)

Creator: Alandini, Nurtalya
Buzzetti, Luca
Favi, Gianfranco
Schulte, Tim
Candish, Lisa
Collins, Karl D.
Melchiorre, Paolo

DOI: 10.1002/ange.202000224

URN: urn:nbn:de:101:1-2022060809523017042551

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:24 AM CEST

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Associated

Alandini, Nurtalya
Buzzetti, Luca
Favi, Gianfranco
Schulte, Tim
Candish, Lisa
Collins, Karl D.
Melchiorre, Paolo

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