Erythrocyte membrane bound and plasma sialic acid during aging
Abstract: Sialic acid, a nine-carbon sugar, is an acetylated derivative of neuraminic acid predominantly found in vertebrates, a few higher invertebrates, and certain types of bacteria. Red blood cells (RBCs) have a net negative surface charge and this bulk charge is due to ionized sialic acid. Decreased surface charge and sialic acid content have been reported in older erythrocytes, and it is postulated that the decreased electro-negativity may be related to cell senescence. In the present study we report the RBC and plasma sialic acid content during aging in rats. Our results show a significant decrease in RBC sialic acid content and increase in plasma sialic acid as a function of rat aging. The decreased sialic acid in erythrocyte membrane with increasing rat age presents a good biomarker of the aging process. The elevated plasma sialic acid may be a manifestation of several factors including increased expression of acute phase proteins and increased damage to various organs.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Erythrocyte membrane bound and plasma sialic acid during aging ; volume:68 ; number:4 ; year:2013 ; pages:762-765 ; extent:4
Biologia ; 68, Heft 4 (2013), 762-765 (gesamt 4)
- Creator
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Kumar, Dileep
Rizvi, Syed
- DOI
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10.2478/s11756-013-0207-1
- URN
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urn:nbn:de:101:1-2409231626059.977164102813
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:34 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Kumar, Dileep
- Rizvi, Syed
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Deformation of the erythrocyte membrane
Biochemische Charakterisierung des Tumormarkers Lipid-bound Sialic Acid (LSA)
Dietary plasmalogen increases erythrocyte membrane plasmalogen in rats
Abnormalities in Erythrocyte Membrane Protein in Pseudohypoparathyroidism Type 1
Structural changes of erythrocyte membrane revealed by 3D confocal optical profilometer
Purification of Membrane-Bound Glycoprotein
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Erythrocyte’s aging in microgravity highlights how environmental stimuli shape metabolism and morphology
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Comparison of the effect of phenoxyherbicides on human erythrocyte membrane (in vitro)
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