A Light‐Triggered Synthetic Nanopore for Controlling Molecular Transport Across Biological Membranes
Abstract: Controlling biological molecular processes with light is of interest in biological research and biomedicine, as light allows precise and selective activation in a non‐invasive and non‐toxic manner. A molecular process benefitting from light control is the transport of cargo across biological membranes, which is conventionally achieved by membrane‐puncturing barrel‐shaped nanopores. Yet, there is also considerable gain in constructing more complex gated pores. Here, we pioneer a synthetic light‐gated nanostructure which controls transport across membranes via a controllable lid. The light‐triggered nanopore is self‐assembled from six pore‐forming DNA strands and a lid strand carrying light‐switchable azobenzene molecules. Exposure to light opens the pore to allow small‐molecule transport across membranes. Our light‐triggered pore advances biomimetic chemistry and DNA nanotechnology and may be used in biotechnology, biosensing, targeted drug release, or synthetic cells.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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A Light‐Triggered Synthetic Nanopore for Controlling Molecular Transport Across Biological Membranes ; day:28 ; month:11 ; year:2022 ; extent:1
Angewandte Chemie / International edition. International edition ; (28.11.2022) (gesamt 1)
- Urheber
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Offenbartl‐Stiegert, Daniel
Rottensteiner, Alexia
Dorey, Adam
Howorka, Stefan
- DOI
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10.1002/anie.202210886
- URN
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urn:nbn:de:101:1-2022112914102082547636
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 15.08.2025, 05:28 UTC
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Offenbartl‐Stiegert, Daniel
- Rottensteiner, Alexia
- Dorey, Adam
- Howorka, Stefan
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