Coding Synthetic Chemistry Strategies for Furan Valorization into Bacterial Designer Cells **
Abstract: Following a synthetic chemistry blueprint for the valorization of lignocellulosic platform chemicals, this study showcases a so far unprecedented approach to implement non‐natural enzyme modules in vivo. For the design of a novel functional whole cell tool, two purely abiotic transformations, a styrene monooxygenase‐catalyzed Achmatowicz rearrangement and an alcohol dehydrogenase‐mediated borrowing hydrogen redox isomerization, were incorporated into a recombinant bacterial host. Introducing this type of chemistry otherwise unknown in biosynthesis, the cellular factories were enabled to produce complex lactone building blocks in good yield from bio‐based furan substrates. This whole cell system streamlined the synthetic cascade, eliminated isolation and purification steps, and provided a high degree of stereoselectivity that has so far been elusive in the chemical methodology.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Coding Synthetic Chemistry Strategies for Furan Valorization into Bacterial Designer Cells ** ; day:12 ; month:12 ; year:2022 ; extent:1
ChemSusChem ; (12.12.2022) (gesamt 1)
- Creator
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Liu, Yu‐Chang
Wu, Zhong‐Liu
Deska, Jan
- DOI
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10.1002/cssc.202201790
- URN
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urn:nbn:de:101:1-2022121314033437714170
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:26 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Liu, Yu‐Chang
- Wu, Zhong‐Liu
- Deska, Jan
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Hydrophobic mismatch drives self-organization of designer proteins into synthetic membranes
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A straightforward chemobiocatalytic route for one-pot valorization of glucose into 2,5-bis(hydroxymethyl)furan
Designer peptide–DNA cytoskeletons regulate the function of synthetic cells
Catalytic 4-exo-dig carbocyclization for the construction of furan-fused cyclobutanones and synthetic applications
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Ein Analysenverfahren zur Bestimmung von Furan in Ausatemluft für ein Biomonitoring Furan-Exponierter
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Über Furan- und Hydrofuran-Verbindungen
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Hydrophobic mismatch drives self-organization of designer proteins into synthetic membranes
Gene Designer: a synthetic biology tool for constructing artificial DNA segments