Hochschulschrift
Biomimetic layers of extracellular matrix glycoproteins as designed biointerfaces
Zusammenfassung: The goal of regenerative medicine is to guide biological systems towards natural healing outcomes using a combination of niche-specific cells, bioactive molecules and biomaterials. In this regard, mimicking the extracellular matrix (ECM) surrounding cells and tissues in vivo is an effective strategy to modulate cell behaviors. Cellular function and phenotype is directed by the biochemical and biophysical signals present in the complex 3D network of ECMs composed mainly of glycoproteins and hydrophilic proteoglycans. While cellular modulation in response to biophysical cues emulating ECM features has been investigated widely, the influence of biochemical display of ECM glycoproteins mimicking their presentation in vivo is not well characterized. It remains a significant challenge to build artificial biointerfaces using ECM glycoproteins that precisely match their presentation in nature in terms of morphology, orientation and conformation. This challenge becomes clear, when one understands how ECM glycoproteins self-assemble in the body. [...].
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Dimensions
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30 cm
- Extent
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1 Band (verschiedene Seitenzählungen)
- Language
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Englisch
- Notes
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Illustrationen, Diagramme
Kumulative Dissertation
Universität Potsdam, Dissertation, 2021
- Classification
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Biowissenschaften, Biologie
Medizin, Gesundheit
- Event
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Veröffentlichung
- (where)
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Potsdam
- (when)
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[2021?]
- Creator
- Contributor
- Table of contents
- Rights
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Bei diesem Objekt liegt nur das Inhaltsverzeichnis digital vor. Der Zugriff darauf ist unbeschränkt möglich.
- Last update
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11.06.2025, 2:15 PM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Object type
- Hochschulschrift
Associated
Time of origin
- [2021?]
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