IFN‐γ stimulates Paneth cell secretion through necroptosis mTORC1 dependent
Abstract: Immune mediators affect multiple biological functions of intestinal epithelial cells (IECs) and, like Paneth and Paneth‐like cells, play an important role in intestinal epithelial homeostasis. IFN‐γ a prototypical proinflammatory cytokine disrupts intestinal epithelial homeostasis. However, the mechanism underlying the process remains unknown. In this study, using in vivo and in vitro models we demonstrate that IFN‐γ is spontaneously secreted in the small intestine. Furthermore, we observed that this cytokine stimulates mitochondrial activity, ROS production, and Paneth and Paneth‐like cell secretion. Paneth and Paneth‐like secretion downstream of IFN‐γ, as identified here, is mTORC1 and necroptosis‐dependent. Thus, our findings revealed that the pleiotropic function of IFN‐γ also includes the regulation of Paneth cell function in the homeostatic gut.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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IFN‐γ stimulates Paneth cell secretion through necroptosis mTORC1 dependent ; day:05 ; month:06 ; year:2024 ; extent:14
European journal of immunology ; (05.06.2024) (gesamt 14)
- Creator
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Encarnacion‐Garcia, Maria R.
De la Torre‐Baez, Raúl
Hernandez‐Cueto, María A.
Velázquez‐Villegas, Laura A.
Candelario‐Martinez, Aurora
Sánchez‐Argáez, Ana Beatriz
Horta‐López, Perla H.
Montoya‐García, Armando
Jaimes‐Ortega, Gustavo Alberto
Lopez‐Bailon, Luis
Piedra‐Quintero, Zayda
Carrasco‐Torres, Gabriela
De Ita, Marlon
Figueroa‐Corona, María del Pilar
Muñoz‐Medina, José Esteban
Sánchez‐Uribe, Magdalena
Ortiz‐Fernández, Arturo
Meraz‐Ríos, Marco Antonio
Silva‐Olivares, Angélica
Betanzos, Abigail
Baay‐Guzman, Guillermina Juliana
Navarro‐Garcia, Fernando
Villa‐Treviño, Saúl
Garcia‐Sierra, Francisco
Cisneros, Bulmaro
Schnoor, Michael
Ortíz‐Navarrete, Vianney F.
Villegas‐Sepúlveda, Nicolás
Valle‐Rios, Ricardo
Medina‐Contreras, Oscar
Noriega, Lilia G.
Nava, Porfirio
- DOI
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10.1002/eji.202350716
- URN
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urn:nbn:de:101:1-2406051414165.317937261579
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:55 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Encarnacion‐Garcia, Maria R.
- De la Torre‐Baez, Raúl
- Hernandez‐Cueto, María A.
- Velázquez‐Villegas, Laura A.
- Candelario‐Martinez, Aurora
- Sánchez‐Argáez, Ana Beatriz
- Horta‐López, Perla H.
- Montoya‐García, Armando
- Jaimes‐Ortega, Gustavo Alberto
- Lopez‐Bailon, Luis
- Piedra‐Quintero, Zayda
- Carrasco‐Torres, Gabriela
- De Ita, Marlon
- Figueroa‐Corona, María del Pilar
- Muñoz‐Medina, José Esteban
- Sánchez‐Uribe, Magdalena
- Ortiz‐Fernández, Arturo
- Meraz‐Ríos, Marco Antonio
- Silva‐Olivares, Angélica
- Betanzos, Abigail
- Baay‐Guzman, Guillermina Juliana
- Navarro‐Garcia, Fernando
- Villa‐Treviño, Saúl
- Garcia‐Sierra, Francisco
- Cisneros, Bulmaro
- Schnoor, Michael
- Ortíz‐Navarrete, Vianney F.
- Villegas‐Sepúlveda, Nicolás
- Valle‐Rios, Ricardo
- Medina‐Contreras, Oscar
- Noriega, Lilia G.
- Nava, Porfirio
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ArfGAP1 inhibits mTORC1 lysosomal localization and activation
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