A persistent prefrontal reference frame across time and task rules

Abstract: Behavior can be remarkably consistent, even over extended time periods, yet whether this is reflected in stable or ‘drifting’ neuronal responses to task features remains controversial. Here, we find a persistently active ensemble of neurons in the medial prefrontal cortex (mPFC) of mice that reliably maintains trajectory-specific tuning over several weeks while performing an olfaction-guided spatial memory task. This task-specific reference frame is stabilized during learning, upon which repeatedly active neurons show little representational drift and maintain their trajectory-specific tuning across long pauses in task exposure and across repeated changes in cue-target location pairings. These data thus suggest a ‘core ensemble’ of prefrontal neurons forming a reference frame of task-relevant space for the performance of consistent behavior over extended periods of time

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• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Nature Communications. - 15, 1 (2024) , 2115, ISSN: 2041-1723

Classification and Topics

• Classification: Medizin, Gesundheit

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2024
• Creator: Muysers, Hannah ; Chen, Hung-Ling ; Hahn, Johannes-Martin ; Folschweiller, Shani ; Sigurdsson, Torfi ; Sauer, Jonas-Frederic ; Bartos, Marlene

Further information

• DOI: 10.1038/s41467-024-46350-4
• URN: urn:nbn:de:bsz:25-freidok-2463450
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.