Flexible Fiber Probe for Efficient Neural Stimulation and Detection
Abstract: Functional probes are a leading contender for the recognition and manipulation of nervous behavior and are characterized by substantial scientific and technological potential. Despite the recent development of functional neural probes, a flexible biocompatible probe unit that allows for long‐term simultaneous stimulation and signaling is still an important task. Here, a category of flexible tiny multimaterial fiber probes (<0.3 g) is described in which the metal electrodes are regularly embedded inside a biocompatible polymer fiber with a double‐clad optical waveguide by thermal drawing. Significantly, this arrangement enables great improvement in mechanical properties, achieves high optical transmission (>90%), and effectively minimizes the impedance (by up to one order of magnitude) of the probe. This ability allows to realize long‐term (at least 10 weeks) simultaneous optical stimulation and neural recording at the single‐cell level in behaving mice with signal‐to‐noise ratio (SNR = 30 dB) that is more than 6 times that of the benchmark probe such as an all‐polymer fiber.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Flexible Fiber Probe for Efficient Neural Stimulation and Detection ; volume:7 ; number:15 ; year:2020 ; extent:11
Advanced science ; 7, Heft 15 (2020) (gesamt 11)
- Urheber
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Du, Minghui
Huang, Lu
Zheng, Jiajun
Xi, Yue
Dai, Yi
Zhang, Weida
Yan, Wei
Tao, Guangming
Qiu, Jianrong
So, Kwok‐Fai
Ren, Chaoran
Zhou, Shifeng
- DOI
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10.1002/advs.202001410
- URN
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urn:nbn:de:101:1-2022062707335346301226
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:29 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Du, Minghui
- Huang, Lu
- Zheng, Jiajun
- Xi, Yue
- Dai, Yi
- Zhang, Weida
- Yan, Wei
- Tao, Guangming
- Qiu, Jianrong
- So, Kwok‐Fai
- Ren, Chaoran
- Zhou, Shifeng
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