BC4707 Is a Major Facilitator Superfamily multidrug resistance transport protein from Bacillus cereus implicated in fluoroquinolone tolerance

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Abstract: Transcriptional profiling highlighted a subset of genes encoding putative multidrug transporters in the pathogen Bacillus cereus that were up-regulated during stress produced by bile salts. One of these multidrug transporters (BC4707) was selected for investigation. Functional characterization of the BC4707 protein in Escherichia coli revealed a role in the energized efflux of xenobiotics. Phenotypic analyses after inactivation of the gene bc4707 in Bacillus cereus ATCC14579 suggested a more specific, but modest role in the efflux of norfloxacin. In addition to this, transcriptional analyses showed that BC4707 is also expressed during growth of B. cereus under non-stressful conditions where it may have a role in the normal physiology of the bacteria. Altogether, the results indicate that bc4707, which is part of the core genome of the B. cereus group of bacteria, encodes a multidrug resistance efflux protein that is likely involved in maintaining intracellular homeostasis during growth of the bacteria

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
ISSN: 1932-6203

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2023
Creator
Simm, Roger
Vörös, Aniko
Ekman, Jaakko V.
Sødring, Marianne
Nes, Ingerid
Kroeger, Jasmin
Saidijam, Massoud
Bettaney, Kim E.
Henderson, Peter J. F.
Salkinoja-Salonen, Mirja
Kolstø, Anne-Brit

DOI
10.1371/journal.pone.0036720
URN
urn:nbn:de:bsz:25-freidok-2390322
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
14.08.2025, 10:56 AM CEST

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Associated

  • Simm, Roger
  • Vörös, Aniko
  • Ekman, Jaakko V.
  • Sødring, Marianne
  • Nes, Ingerid
  • Kroeger, Jasmin
  • Saidijam, Massoud
  • Bettaney, Kim E.
  • Henderson, Peter J. F.
  • Salkinoja-Salonen, Mirja
  • Kolstø, Anne-Brit
  • Universität

Time of origin

  • 2023

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