Strain‐Release‐Driven Modular Synthesis of Oxetane‐Based Amide Bioisosteres: Concise, Robust and Scalable Approach
Abstract: Amide bioisoterism is a widely used strategy in drug development to fine‐tune physicochemical, pharmacokinetic, and metabolic properties, eliminate toxicity and gain intellectual property rights in uncharted chemical space. Of these, oxetane‐amines offer particularly exciting possibilities as bioisosteres, although they are less frequently investigated than warranted due to the lack of simple and widely applicable synthetic methods. Herein, we report a two‐step, practical, modular, robust, and scalable method for the construction of oxetane‐containing amide bioisosteres that relies on the readily available oxetan‐3‐one. This operationally simple procedure exploits the enhanced reactivity of the keto group of the commercially available oxetan‐3‐one to form amine‐benzotriazole intermediates, which springloaded adducts are then reacted with various aliphatic and aromatic organometallic reagents under mild conditions to afford various amino‐oxetanes in good to high yields. The simplicity and broad applicability of the method greatly facilitates the synthesis of derivatives that were previously difficult or impossible to produce. The usefulness of this method in the field medicinal chemistry was also demonstrated by eliminating the well‐known metabolic problem of ketoconazole.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Strain‐Release‐Driven Modular Synthesis of Oxetane‐Based Amide Bioisosteres: Concise, Robust and Scalable Approach ; volume:136 ; number:42 ; year:2024 ; extent:6
Angewandte Chemie ; 136, Heft 42 (2024) (gesamt 6)
- Creator
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Spránitz, Péter
Sőregi, Petra
Hegedüs, Kristóf
Igriczi, Barbara
Szakács, Gergely
Jemnitz, Katalin
Szabó, Pál
Galushchak, Yarema
Mykhailiuk, Pavel K.
Soós, Tibor
- DOI
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10.1002/ange.202410554
- URN
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urn:nbn:de:101:1-2410071429230.290879010582
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Spránitz, Péter
- Sőregi, Petra
- Hegedüs, Kristóf
- Igriczi, Barbara
- Szakács, Gergely
- Jemnitz, Katalin
- Szabó, Pál
- Galushchak, Yarema
- Mykhailiuk, Pavel K.
- Soós, Tibor
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Nachhaltige Weiterentwicklung von modularen Produktarchitekturen durch Release-Management
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Concise and Scalable Synthesis of Thalidomide
RELEASE Scalable Erlang
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Advances in the Release of Amide‐Containing Molecules
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Rapid and Scalable Halosulfonylation of Strain‐Release Reagents **
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