Fmoc-diphenylalanine-based hydrogels as a potential carrier for drug delivery

Abstract: Self-assembled hydrogels from 9-fluorenylmethoxycarbonyl-modified diphenylalanine (Fmoc-FF) peptides were evaluated as potential vehicles for drug delivery. During self-assembly of Fmoc-FF, high concentrations of indomethacin (IDM) drugs were shown to be incorporated into the hydrogels. The β-sheet arrangement of peptides was found to be predominant in Fmoc-FF–IDM hydrogels regardless of the IDM content. The release mechanism for IDM displayed a biphasic profile comprising an initial hydrogel erosion-dominated stage followed by the diffusion-controlled stage. Small amounts of polyamidoamine dendrimer (PAMAM) added to the hydrogel (Fmoc-FF 0.5%–IDM 0.5%–PAMAM 0.03%) resulted in a more prolonged IDM release compared with Fmoc-FF 0.5%–IDM 0.5% hydrogel. Furthermore, these IDM-loaded hydrogels demonstrated excellent thixotropic response and injectability, which make them suitable candidates for use as injectable self-healing matrices for drug delivery.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Fmoc-diphenylalanine-based hydrogels as a potential carrier for drug delivery ; volume:20 ; number:1 ; year:2020 ; pages:458-468 ; extent:11 ; e-Polymers ; 20, Heft 1 (2020), 458-468 (gesamt 11)

Beteiligte, Orts- und Zeitangaben

• Urheber: Choe, Ranjoo ; Il Yun, Seok

Weitere Informationen

• DOI: 10.1515/epoly-2020-0050
• URN: urn:nbn:de:101:1-2412151557439.154763775447
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:34 MESZ