Synthesis and antimicrobial activity of derivatives of 1H -benzo (de) isoquinoline-1,3 (2H)-dione

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Abstract: Five aminoalkyl 1H-benzo[de]isoquinoline-1,3 (2H)-diones were synthesized and evaluated for antimicrobial activity. Microorganisms used in this study included aerobic and facultative anaerobic bacteria Staphylococcus aureus, Escherichia coli and Stenotrophomonas maltophilia, and obligatory anaerobes Bacteroides fragilis, Bacteroides thetaiotaomicron and Propionibacterium acnes. Moreover, Candida albicans yeast was used. The minimum inhibitory concentration (MIC) was determined for the test compounds. Among the tested derivatives, two compounds 1 and 2 have shown the most potent antibacterial as well as antifungal activities.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Synthesis and antimicrobial activity of derivatives of 1H -benzo (de) isoquinoline-1,3 (2H)-dione ; volume:18 ; number:5-6 ; year:2012 ; pages:275-278
Heterocyclic communications ; 18, Heft 5-6 (2012), 275-278

Creator
Kuran, Bożena
Krawiecka, Mariola
Kossakowski, Jerzy
Szymanek, Ksenia
Kierzkowska, Marta
Młynarczyk, Grażyna

DOI
10.1515/hc-2012-0115
URN
urn:nbn:de:101:1-2501130545459.636592873326
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:23 AM CEST

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Associated

  • Kuran, Bożena
  • Krawiecka, Mariola
  • Kossakowski, Jerzy
  • Szymanek, Ksenia
  • Kierzkowska, Marta
  • Młynarczyk, Grażyna

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