Directed Palladium Catalyzed C−H (Ethoxycarbonyl) difluoromethylthiolation Reactions
Abstract: The unprecedented Pd‐catalyzed (ethoxycarbonyl) difluoromethylthiolation reaction of various unsaturated derivatives was studied. In the presence of the (ethoxycarbonyl) difluoromethylsulfenamide reagent I and under mild reaction conditions (60 °C), both 2‐(hetero) aryl and 2‐(α‐aryl‐vinyl) pyridine derivatives were smoothly functionalized with this methodology (37 examples, up to 87 % yield). Moreover, the synthetic interest of this fluorinated moiety was further showcased by its conversion into various original fluorinated residues. Finally, a plausible mechanism for this transformation was suggested.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Directed Palladium Catalyzed C−H (Ethoxycarbonyl) difluoromethylthiolation Reactions ; day:13 ; month:09 ; year:2022 ; extent:1
Chemistry - a European journal ; (13.09.2022) (gesamt 1)
- Creator
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Doche, Floriane
Escudero, Julien
Petit‐Cancelier, Fabien
Xiong, Heng‐Ying
Couve‐Bonnaire, Samuel
Audisio, Davide
Poisson, Thomas
Besset, Tatiana
- DOI
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10.1002/chem.202202099
- URN
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urn:nbn:de:101:1-2022091315185052245324
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:39 AM CEST
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Associated
- Doche, Floriane
- Escudero, Julien
- Petit‐Cancelier, Fabien
- Xiong, Heng‐Ying
- Couve‐Bonnaire, Samuel
- Audisio, Davide
- Poisson, Thomas
- Besset, Tatiana
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