The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans

Abstract: Multicellular organisms coordinate tissue specific responses to environmental information via both cell-autonomous and non-autonomous mechanisms. In addition to secreted ligands, recent reports implicated release of small RNAs in regulating gene expression across tissue boundaries. Here, we show that the conserved poly-U specific endoribonuclease ENDU-2 in C. elegans is secreted from the soma and taken-up by the germline to ensure germline immortality at elevated temperature. ENDU-2 binds to mature mRNAs and negatively regulates mRNA abundance both in the soma and the germline. While ENDU-2 promotes RNA decay in the soma directly via its endoribonuclease activity, ENDU-2 prevents misexpression of soma-specific genes in the germline and preserves germline immortality independent of its RNA-cleavage activity. In summary, our results suggest that the secreted RNase ENDU-2 regulates gene expression across tissue boundaries in response to temperature alterations and contributes to maintenance of stem cell immortality, probably via retaining a stem cell specific program of gene expression

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• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Nature communications. - 12, 1 (2021) , 1262, ISSN: 2041-1723

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2021
• Urheber: Qi, Wenjing ; Donner von Gromoff, Erika ; Xu, Fan ; Zhao, Qian ; Yang, Wei ; Pfeifer, Dietmar ; Maier, Wolfgang ; Long, Lijiang ; Baumeister, Ralf

Weitere Informationen

• DOI: 10.1038/s41467-021-21516-6
• URN: urn:nbn:de:bsz:25-freidok-1943730
• Rechteinformation: Der Zugriff auf das Objekt ist unbeschränkt möglich.