Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids

to related objects

Abstract: DNA and RNA play pivotal roles in life processes by storing and transferring genetic information, modulating gene expression, and contributing to essential cellular machinery such as ribosomes. Dysregulation and mutations in nucleic acid‐related processes are implicated in numerous diseases. Despite the critical impact on health of nucleic acid mutations or dysregulation, therapeutic compounds addressing these biomolecules remain limited. Peptides have emerged as a promising class of molecules for biomedical research, offering potential solutions for challenging drug targets. This review focuses on the use of synthetic peptides to target disease‐related nucleic acids. We discuss examples of peptides targeting double‐stranded DNA, including the clinical candidate Omomyc, and compounds designed for regulatory G‐quadruplexes. Further, we provide insights into both library‐based screenings and the rational design of peptides to target regulatory human RNA scaffolds and viral RNAs, emphasizing the potential of peptides in addressing nucleic acid‐related diseases.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids ; day:09 ; month:04 ; year:2024 ; extent:21
Angewandte Chemie ; (09.04.2024) (gesamt 21)

Creator: Ellenbroek, Brecht D.
Kahler, Jan Pascal
Evers, Sophie R.
Pomplun, Sebastian J.

DOI: 10.1002/ange.202401704

URN: urn:nbn:de:101:1-2024041014365775011012

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 11:00 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Ellenbroek, Brecht D.
Kahler, Jan Pascal
Evers, Sophie R.
Pomplun, Sebastian J.

Other Objects (12)

Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids

Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids

Protein based nanomedicine: Promising therapeutic modalities against inflammatory disorders

Protein based nanomedicine: Promising therapeutic modalities against inflammatory disorders

Post-transcriptional regulation via nucleic acid binding events and disease-related mutations in vertebrates

Hochschulschrift

Post-transcriptional regulation via nucleic acid binding events and disease-related mutations in vertebrates

Antimicrobial peptides: an overview of a promising class of therapeutics

Antimicrobial peptides: an overview of a promising class of therapeutics

Conditional Activation and Synergistic Enhancement of Smac Mimetic Peptides with Nucleic Acids

Conditional Activation and Synergistic Enhancement of Smac Mimetic Peptides with Nucleic Acids

Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids

Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids

Selective Interaction of Chiral Carbon Dots with Nucleic Acids: A Promising Nanosensing Platform

Selective Interaction of Chiral Carbon Dots with Nucleic Acids: A Promising Nanosensing Platform

Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics

Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics

Nature-derived Peptides as Promising Antiparasitic Agents against Neglected Tropical Diseases

Nature-derived Peptides as Promising Antiparasitic Agents against Neglected Tropical Diseases

Alethic Modalities, Temporal Modalities, and Representation

Alethic Modalities, Temporal Modalities, and Representation

Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides

Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides

Host defence peptides identified in human apolipoprotein B as promising antifungal agents

Host defence peptides identified in human apolipoprotein B as promising antifungal agents

Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids

Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids

Protein based nanomedicine: Promising therapeutic modalities against inflammatory disorders

Protein based nanomedicine: Promising therapeutic modalities against inflammatory disorders

Post-transcriptional regulation via nucleic acid binding events and disease-related mutations in vertebrates

Hochschulschrift

Post-transcriptional regulation via nucleic acid binding events and disease-related mutations in vertebrates

Antimicrobial peptides: an overview of a promising class of therapeutics

Antimicrobial peptides: an overview of a promising class of therapeutics

Conditional Activation and Synergistic Enhancement of Smac Mimetic Peptides with Nucleic Acids

Conditional Activation and Synergistic Enhancement of Smac Mimetic Peptides with Nucleic Acids

Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids

Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids

Selective Interaction of Chiral Carbon Dots with Nucleic Acids: A Promising Nanosensing Platform

Selective Interaction of Chiral Carbon Dots with Nucleic Acids: A Promising Nanosensing Platform

Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics

Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics

Nature-derived Peptides as Promising Antiparasitic Agents against Neglected Tropical Diseases

Nature-derived Peptides as Promising Antiparasitic Agents against Neglected Tropical Diseases

Alethic Modalities, Temporal Modalities, and Representation

Alethic Modalities, Temporal Modalities, and Representation

Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides

Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides

Host defence peptides identified in human apolipoprotein B as promising antifungal agents

Host defence peptides identified in human apolipoprotein B as promising antifungal agents

Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids

Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids

Protein based nanomedicine: Promising therapeutic modalities against inflammatory disorders

Protein based nanomedicine: Promising therapeutic modalities against inflammatory disorders

Post-transcriptional regulation via nucleic acid binding events and disease-related mutations in vertebrates

Hochschulschrift

Post-transcriptional regulation via nucleic acid binding events and disease-related mutations in vertebrates

Antimicrobial peptides: an overview of a promising class of therapeutics

Antimicrobial peptides: an overview of a promising class of therapeutics

Conditional Activation and Synergistic Enhancement of Smac Mimetic Peptides with Nucleic Acids

Conditional Activation and Synergistic Enhancement of Smac Mimetic Peptides with Nucleic Acids

Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids

Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids

Selective Interaction of Chiral Carbon Dots with Nucleic Acids: A Promising Nanosensing Platform

Selective Interaction of Chiral Carbon Dots with Nucleic Acids: A Promising Nanosensing Platform

Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics

Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics

Nature-derived Peptides as Promising Antiparasitic Agents against Neglected Tropical Diseases

Nature-derived Peptides as Promising Antiparasitic Agents against Neglected Tropical Diseases

Alethic Modalities, Temporal Modalities, and Representation

Alethic Modalities, Temporal Modalities, and Representation

Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides

Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides

Host defence peptides identified in human apolipoprotein B as promising antifungal agents

Host defence peptides identified in human apolipoprotein B as promising antifungal agents

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.