Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting

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Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: 1 Online-Ressource.

Language: Englisch

Bibliographic citation: Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting ; volume:14 ; number:1 ; day:29 ; month:11 ; year:2023 ; pages:1-16 ; date:12.2023
Nature Communications ; 14, Heft 1 (29.11.2023), 1-16, 12.2023

Creator: Ronson, George E.
Starowicz, Katarzyna
Anthony, Elizabeth J.
Piberger, Ann Liza
Clarke, Lucy C.
Garvin, Alexander J.
Beggs, Andrew D.
Whalley, Celina M.
Edmonds, Matthew J.
Beesley, James F. J.
Morris, Joanna R.

Contributor: SpringerLink (Online service)

DOI: 10.1038/s41467-023-43677-2

URN: urn:nbn:de:101:1-2024021521175913489176

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:28 AM CEST

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Associated

Ronson, George E.
Starowicz, Katarzyna
Anthony, Elizabeth J.
Piberger, Ann Liza
Clarke, Lucy C.
Garvin, Alexander J.
Beggs, Andrew D.
Whalley, Celina M.
Edmonds, Matthew J.
Beesley, James F. J.
Morris, Joanna R.
SpringerLink (Online service)

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Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting

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Other Objects (12)

The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells

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The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis

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The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells

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The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis

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Are There Deficiencies?

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Exploiting Synthetic lethality between Germline BRCA1 haploinsufficiency and PARP inhibition in JAK2V617F-positive myeloproliferative neoplasms

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