Infusion-Related Reactions Induced by Cadonilimab (PD-1/CTLA-4 Bispecific Antibody): Seven Case Reports
Abstract: Introduction: Cadonilimab (AK104) is an innovative human programmed cell death-1 (PD-1)/cytotoxic T lymphocyte antigen-4 (CTLA-4) bispecific antibody. Compared with the combination therapy of PD-1 and CTLA-4 blockers, less cellular toxicity of cadonilimab was significantly manifested. As one of the characteristic adverse effects of cadonilimab, infusion-related reactions (IRRs) represent fever, chills, rash, decreased blood pressure, and other symptoms. Case Presentation: Here, we documented seven cases of IRRs after the administration of cadonilimab. The symptoms of IRRs were relieved after the discontinuation of cadonilimab and the administration of diphenhydramine, dexamethasone, and cimetidine. Notably, 3 patients were able to tolerate the subsequent cadonilimab therapy under the pretreatment. Conclusion: In this study, we discovered that cadonilimab-related IRRs might be lessened or prevented by administering medication and the proper pretreatment and lowering the infusion rate.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Infusion-Related Reactions Induced by Cadonilimab (PD-1/CTLA-4 Bispecific Antibody): Seven Case Reports ; volume:17 ; number:1 ; year:2024 ; pages:361-369 ; extent:9
Case reports in oncology ; 17, Heft 1 (2024), 361-369 (gesamt 9)
- Urheber
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Liang, Weiting
Guo, Zhijun
Zhang, Yunhui
Yang, Ning
Guo, Chenchen
Liu, Tao
Huang, Hongbing
Chen, Zhuojia
- DOI
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10.1159/000535504
- URN
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urn:nbn:de:101:1-2406270058301.575707332899
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:03 MESZ
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Beteiligte
- Liang, Weiting
- Guo, Zhijun
- Zhang, Yunhui
- Yang, Ning
- Guo, Chenchen
- Liu, Tao
- Huang, Hongbing
- Chen, Zhuojia
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