Fetal Thyrotoxicosis due to Maternal TSH Receptor Stimulating Antibodies Causes Infant Central Hypothyroidism
Introduction: Women with a current diagnosis or past history of Graves’ disease (GD) are at risk of developing fetal thyrotoxicosis (FT) during pregnancy when they are inadequately treated, or because of placental passage of TSH receptor antibodies (TRAb). It is known that FT induced by high maternal thyroid hormone concentrations may result in infant (central) hypothyroidism. Case Presentation: In a euthyroid woman with a history of GD treated with radioactive iodide (I131), persistently high levels of maternal TRAb resulted in recurrent FT during two separate pregnancies, followed by neonatal hyperthyroidism and infant central hypothyroidism. Discussion: This case demonstrates the novel insight that FT due to high fetal thyroid hormone concentrations stimulated by high maternal TRAb levels might also result in (central) hypothyroidism, requiring long-term evaluation of the hypothalamus-pituitary-thyroid axis in these children.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Fetal Thyrotoxicosis due to Maternal TSH Receptor Stimulating Antibodies Causes Infant Central Hypothyroidism ; volume:97 ; number:2 ; year:2024 ; pages:180-186 ; extent:7
Hormone research in paediatrics ; 97, Heft 2 (2024), 180-186 (gesamt 7)
- Creator
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van Hulsteijn, Leonie T.
Prins, Jelmer R.
Scheffer-Rath, Mirjam E.A.
van Trotsenburg, A.S. Paul
Links, Thera P.
Dullaart, Robin P.F.
- DOI
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10.1159/000530725
- URN
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urn:nbn:de:101:1-2404180021553.507246023257
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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2025-08-14T11:02:40+0200
Data provider
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Associated
- van Hulsteijn, Leonie T.
- Prins, Jelmer R.
- Scheffer-Rath, Mirjam E.A.
- van Trotsenburg, A.S. Paul
- Links, Thera P.
- Dullaart, Robin P.F.
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Percentile transformation and recalibration functions allow harmonization of thyroid-stimulating hormone (TSH) immunoassay results
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Graves’ Disease Mechanisms: The Role of Stimulating, Blocking, and Cleavage Region TSH Receptor Antibodies
Comparison Between Thyroid Stimulating Immunoglobulin and TSH-Receptor Antibodies in the Management of Graves’ Orbitopathy
Deciphering the roles of triiodothyronine (T3) and thyroid-stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism
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Coexistence of TSH-secreting adenoma and primary hypothyroidism: a case report and review of literature
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