Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors
Abstract: General methods to prepare chiral N‐heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2‐ and 4‐substituted tetrahydro‐quinolones, dihydro‐4‐pyridones, and piperidones with excellent yields and enantioselectivities, utilizing a single catalyst system.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors ; volume:131 ; number:37 ; year:2019 ; pages:13084-13088 ; extent:5
Angewandte Chemie ; 131, Heft 37 (2019), 13084-13088 (gesamt 5)
- Urheber
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Guo, Yafei
Harutyunyan, Syuzanna R.
- DOI
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10.1002/ange.201906237
- URN
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urn:nbn:de:101:1-2022073112360227357480
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:28 MESZ
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Beteiligte
- Guo, Yafei
- Harutyunyan, Syuzanna R.
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