Ferroptosis-related prognostic model of mantle cell lymphoma
Background: Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin’s lymphoma. Ferroptosis, an iron-dependent programmed cell death, is closely related to cancer prognosis. In this study, we established a model of ferroptosis related genes for prognostic evaluation of patients with MCL. Methods: Using the single-cell RNA sequencing datasets GSE184031 and mRNA sequencing data GSE32018 from the Gene Expression Omnibus, we identified 139 ferroptosis-related genes in MCL. Next a prognostic model was constructed by Cox regression and Least absolute selection and shrinkage Operator regression analysis. Finally, we used CIBERSORT to analyze the immune microenvironment and the “oncoPredict” package to predict potential drugs. Results: In our model, the prognosis of MCL patients was assessed by risk scoring using 7 genes ANXA1, IL1B, YBX1, CCND1, MS4A1, MFHAS1, and RILPL2. The patients were divided into high-risk and low-risk groups based on our model, and the high-risk patients had inferior overall survival. Finally, according to our model and computational drug sensitivity analysis, four small molecule compounds, BMS-754807, SB216763, Doramapimod, and Trametinib, were identified as potential therapeutic agents for patients with MCL. Conclusion: In summary, we provide a prognostic model with ferroptosis-related gene signature for MCL. This study provides a prognostic model with ferroptosis-related gene signature for MCL. The results show that the model helps predict prognosis in MCL.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Ferroptosis-related prognostic model of mantle cell lymphoma ; volume:19 ; number:1 ; year:2024 ; extent:13
Open medicine ; 19, Heft 1 (2024) (gesamt 13)
- Urheber
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Gao, Qianwen
Wang, Xin
Zhang, Yue
Wen, Jingjing
Wang, Fangfang
Lin, Zhimei
Feng, Yu
Huang, Jingcao
Li, Qian
Luo, Hongmei
Liu, Xiang
Zhai, Xinyu
Li, Linfeng
He, Siyao
Mi, Ziyue
Zhang, Li
Niu, Ting
Xu, Caigang
Zheng, Yuhuan
- DOI
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10.1515/med-2024-1090
- URN
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urn:nbn:de:101:1-2411211600066.798453634645
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:28 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Gao, Qianwen
- Wang, Xin
- Zhang, Yue
- Wen, Jingjing
- Wang, Fangfang
- Lin, Zhimei
- Feng, Yu
- Huang, Jingcao
- Li, Qian
- Luo, Hongmei
- Liu, Xiang
- Zhai, Xinyu
- Li, Linfeng
- He, Siyao
- Mi, Ziyue
- Zhang, Li
- Niu, Ting
- Xu, Caigang
- Zheng, Yuhuan
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