Selective Arene Hydrogenation for Direct Access to Saturated Carbo‐ and Heterocycles
Abstract: Arene hydrogenation provides direct access to saturated carbo‐ and heterocycles and thus its strategic application may be used to shorten synthetic routes. This powerful transformation is widely applied in industry and is expected to facilitate major breakthroughs in the applied sciences. The ability to overcome aromaticity while controlling diastereo‐, enantio‐, and chemoselectivity is central to the use of hydrogenation in the preparation of complex molecules. In general, the hydrogenation of multisubstituted arenes yields predominantly the cis isomer. Enantiocontrol is imparted by chiral auxiliaries, Brønsted acids, or transition‐metal catalysts. Recent studies have demonstrated that highly chemoselective transformations are possible. Such methods and the underlying strategies are reviewed herein, with an emphasis on synthetically useful examples that employ readily available catalysts.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Selective Arene Hydrogenation for Direct Access to Saturated Carbo‐ and Heterocycles ; volume:58 ; number:31 ; year:2019 ; pages:10460-10476 ; extent:17
Angewandte Chemie / International edition. International edition ; 58, Heft 31 (2019), 10460-10476 (gesamt 17)
- Creator
- DOI
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10.1002/anie.201814471
- URN
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urn:nbn:de:101:1-2022080806411919530204
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:25 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wiesenfeldt, Mario P.
- Nairoukh, Zackaria
- Dalton, Toryn
- Glorius, Frank
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