Short-term dietary intervention with cooked but not raw brassica leafy vegetables increases telomerase activity in CD8+ lymphocytes in a randomized human trial

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Abstract: Telomerase in T lymphocytes is dynamic and limited evidence from epidemiological studies indicates that the enzyme can be modulated in peripheral lymphocytes by dietary and lifestyle factors. The differential effect of dietary intervention on T cell subsets has not been investigated so far. Brassica vegetables are known for their multiple beneficial effects on human health, and here, the effect of a five-day short-term intervention with raw or cooked leaves of Brassica carinata on telomerase activity in CD4+ and CD8+ T cells from 22 healthy volunteers was investigated in a randomized single-blind, controlled crossover study. Blood samples were collected before and after intervention, and CD4+/CD8+ T lymphocytes were isolated. Telomerase activity was quantified using the TRAP-ELISA assay. Intervention with both preparations led to a marginal increase in telomerase activity of CD4+ cells compared to the baseline level. In CD8+ cells, a significant increase in telomerase activity (25%, p < 0.05) was seen after intervention with the cooked material. An increase in telomerase activity in CD8+ cells of healthy volunteers could be regarded as beneficial in terms of helping with the cell-mediated immune response. Whether a Brassica intervention has long-term effects on telomere extension in specific T cell subsets needs to be determined

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: issn: 2072-6643

Classification: Medizin, Gesundheit

Keyword: Kohl
Polyphenole
Isothiocyanate
Telomerase
T-Lymphozyt

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2019

Creator: Tran, Hoai Thi Thu
Schlotz, Nina
Schreiner, Monika
Lamy, Evelyn

DOI: 10.3390/nu11040786

URN: urn:nbn:de:bsz:25-freidok-1496880

Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:50 AM CEST

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2019

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Short-Term Dietary Intervention with Cooked but Not Raw Brassica Leafy Vegetables Increases Telomerase Activity in CD8+ Lymphocytes in a Randomized Human Trial

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Short-term dietary intervention with cooked but not raw brassica leafy vegetables increases telomerase activity in CD8+ lymphocytes in a randomized human trial

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Other Objects (12)

Short-Term Dietary Intervention with Cooked but Not Raw Brassica Leafy Vegetables Increases Telomerase Activity in CD8+ Lymphocytes in a Randomized Human Trial

Short-term dietary intervention with cooked but not raw brassica leafy vegetables increases telomerase activity in CD8+ lymphocytes in a randomized human trial

Preclinical evaluation of isothiocyanates for tumour preventive and therapeutic application

MTBITC-induced apoptosis and cell cycle arrest of human hepatoma (HepG2) cells : a link between p53 and human telomerase?

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Subsequent treatment of leafy vegetables with low doses of UVB-radiation does not provoke cytotoxicity, genotoxicity, or oxidative stress in a human liver cell model

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Short-Term Dietary Intervention with Cooked but Not Raw Brassica Leafy Vegetables Increases Telomerase Activity in CD8+ Lymphocytes in a Randomized Human Trial

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MTBITC-induced apoptosis and cell cycle arrest of human hepatoma (HepG2) cells : a link between p53 and human telomerase?

Development of an inflammation-triggered in vitro “leaky gut” model using Caco-2/HT29-MTX-E12 combined with macrophage-like THP-1 cells or primary human-derived macrophages

Long-term exposure to “low-dose” bisphenol A decreases mitochondrial DNA copy number, and accelerates telomere shortening in human CD8 + T cells

BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry

Subsequent treatment of leafy vegetables with low doses of UVB-radiation does not provoke cytotoxicity, genotoxicity, or oxidative stress in a human liver cell model

Low-dose levels of bisphenol A inhibit telomerase via ER/GPR30-ERK signalling, impair DNA integrity and reduce cell proliferation in primary PBMC

Are Raw Brassica Vegetables Healthier Than Cooked Ones? : A Randomized, Controlled Crossover Intervention Trial on the Health-Promoting Potential of Ethiopian Kale

Subsequent treatment of leafy vegetables with low doses of UVB-radiation does not provoke cytotoxicity, genotoxicity, or oxidative stress in a human liver cell model

The MAPK pathway signals telomerase modulation in response to isothiocyanate-induced DNA damage of human liver cancer cells

Short-Term Dietary Intervention with Cooked but Not Raw Brassica Leafy Vegetables Increases Telomerase Activity in CD8+ Lymphocytes in a Randomized Human Trial

Short-term dietary intervention with cooked but not raw brassica leafy vegetables increases telomerase activity in CD8+ lymphocytes in a randomized human trial

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MTBITC-induced apoptosis and cell cycle arrest of human hepatoma (HepG2) cells : a link between p53 and human telomerase?

Development of an inflammation-triggered in vitro “leaky gut” model using Caco-2/HT29-MTX-E12 combined with macrophage-like THP-1 cells or primary human-derived macrophages

Long-term exposure to “low-dose” bisphenol A decreases mitochondrial DNA copy number, and accelerates telomere shortening in human CD8 + T cells

BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry

Subsequent treatment of leafy vegetables with low doses of UVB-radiation does not provoke cytotoxicity, genotoxicity, or oxidative stress in a human liver cell model

Low-dose levels of bisphenol A inhibit telomerase via ER/GPR30-ERK signalling, impair DNA integrity and reduce cell proliferation in primary PBMC

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