The influence of antibiotic administration on the outcomes of head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiation
Abstract: Purpose
Effects of antibiotic administration on patients’ microbiome may negatively influence cancer outcomes, and adverse prognoses after antibiotic application have been demonstrated for cancer patients receiving immune checkpoint inhibitors. While the microbiome may play an important role also in head-and-neck squamous cell carcinoma (HNSCC), the prognostic value of antibiotic treatment here is largely unknown. We therefore analyzed whether antibiotic prescription is associated with impaired oncological outcomes of HNSCC patients undergoing definitive (chemo)radiation.
Methods
A cohort of 220 HNSCC patients undergoing definitive (chemo)radiation between 2010 and 2019 was analyzed. The influence of antibiotic administration on locoregional control, progression-free survival (PFS) and overall survival (OS) was determined using Kaplan–Meier and Cox analyses.
Results
A total of 154 patients were treated with antibiotics within 30 days before (chemo)radiation (pretherapeutic) or during (chemo)radiation (peritherapeutic). While antibiotic prescription was not associated with age, ECOG, tumor localization or radiotherapy characteristics, patients treated with antibiotics had significantly higher tumor stages. Peritherapeutic antibiotic administration diminished PFS (HR = 1.397, p < 0.05, log-rank test) and OS (HR = 1.407, p < 0.05), whereas pretherapeutic administration did not. Antibiotic application was an independent prognosticator for OS (HR = 1.703, p < 0.05) and PFS (HR = 1.550, p < 0.05) in the multivariate Cox analysis within the subgroup of patients aged < 75 years.
Conclusion
Peritherapeutic antibiotic usage was associated with impaired oncological outcomes in HNSCC patients undergoing (chemo)radiation. Further studies including microbiome analyses are required to elucidate underlying mechanisms
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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European archives of oto-rhino-laryngology and head & neck. - 280, 5 (2023) , 2605-2616, ISSN: 1434-4726
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2023
- Creator
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Rühle, Alexander
Zou, Jiadai
Glaser, Margaretha
Halle, Lennard
Gkika, Eleni
Schäfer, Henning Sebastian
Knopf, Andreas
Becker, Christoph
Grosu, Anca-Ligia
Popp, Ilinca
Nicolay, Nils
- DOI
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10.1007/s00405-023-07868-3
- URN
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urn:nbn:de:bsz:25-freidok-2334810
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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25.03.2025, 1:43 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Rühle, Alexander
- Zou, Jiadai
- Glaser, Margaretha
- Halle, Lennard
- Gkika, Eleni
- Schäfer, Henning Sebastian
- Knopf, Andreas
- Becker, Christoph
- Grosu, Anca-Ligia
- Popp, Ilinca
- Nicolay, Nils
- Universität
Time of origin
- 2023
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