Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding
Abstract: Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template‐based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia‐inducible transcription factor prolyl hydroxylase, PHD2.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding ; volume:25 ; number:8 ; year:2019 ; pages:2019-2024 ; extent:6
Chemistry - a European journal ; 25, Heft 8 (2019), 2019-2024 (gesamt 6)
- Urheber
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Thinnes, Cyrille C.
Lohans, Christopher T.
Abboud, Martine I.
Yeh, Tzu‐Lan
Tumber, Anthony
Nowak, Radosław P.
Attwood, Martin
Cockman, Matthew E.
Oppermann, Udo
Lönarz, Christoph
Schofield, Christopher
- DOI
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10.1002/chem.201804790
- URN
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urn:nbn:de:101:1-2022071407243677168751
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:31 MESZ
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Beteiligte
- Thinnes, Cyrille C.
- Lohans, Christopher T.
- Abboud, Martine I.
- Yeh, Tzu‐Lan
- Tumber, Anthony
- Nowak, Radosław P.
- Attwood, Martin
- Cockman, Matthew E.
- Oppermann, Udo
- Lönarz, Christoph
- Schofield, Christopher
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