Recent Advances in Catalytic Desymmetrization for the Synthesis of Axially Chiral Biaryls

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Abstract: Atropisomeric compounds have been discovered in pharmaceuticals and materials science, and their enantioselective syntheses have gained tremendous attention. Among strategies for catalytic atroposelective synthesis, desymmetrization provides robust and straightforward approaches to axially chiral biaryls. Due to the relative ease of substrate design compared to other atroposelective strategies, desymmetrization has emerged as a pivotal stage for converting fascinating chemistry into its atroposelective counterpart, despite challenges such as the formation of achiral products by subsequent catalytic reactions and the long distance between the reaction site and the stereogenic axis. This review offers a comprehensive overview of recent advancements in atroposelective desymmetrization using chiral organo‐ and metal catalysts, addressing challenges and solutions, and aims to provide insights into future developments in this field.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Recent Advances in Catalytic Desymmetrization for the Synthesis of Axially Chiral Biaryls ; day:31 ; month:07 ; year:2024 ; extent:14
ChemCatChem ; (31.07.2024) (gesamt 14)

Creator: Moon, Junsoo
Kim, Sangji
Lee, Sujin
Cho, Hyun‐A
Kim, Ahreum
Ham, Min Kyung
Kim, Seung Hyun
Jung, Jaeyoung
Kwon, Yongseok

DOI: 10.1002/cctc.202400690

URN: urn:nbn:de:101:1-2408011408167.932987772725

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:48 AM CEST

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Moon, Junsoo
Kim, Sangji
Lee, Sujin
Cho, Hyun‐A
Kim, Ahreum
Ham, Min Kyung
Kim, Seung Hyun
Jung, Jaeyoung
Kwon, Yongseok

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Recent Advances in Catalytic Desymmetrization for the Synthesis of Axially Chiral Biaryls

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Other Objects (12)

Recent advances in the asymmetric phosphoric acid-catalyzed synthesis of axially chiral compounds

Catalytic Atroposelective Synthesis of C−N Axially Chiral Aminophosphines via Dynamic Kinetic Resolution

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Catalytic Enantioselective Synthesis of Axially Chiral Diaryl Ethers Via Asymmetric Povarov Reaction Enabled Desymmetrization

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