Arbeitspapier

Costs and quality of life in multiple sclerosis: A cross-sectional observational study in the UK

We performed a cross-sectional, bottom-up observational study of resource consumption and quality of life of patients with multiple sclerosis (MS) in the United Kingdom. Three centers participated in the study. Patients received a questionnaire either by mail or during a clinic visit, and a total of 619 patients returned the questionnaire (the answer rate being around 70%). Patients provided information on all resource consumption, medical and non-medical, work absence and informal care related to their MS. Disease scores (Expanded Disability Status Scale, EDSS) were available for a majority of patients from the study centers, and were assigned using a matrix of disease (mobility) descriptions and EDSS scores. Mean total cost per patient and year was 16'717 £. When this cost is extrapolated to an estimated patient population in the UK of 80'000, total costs to society are estimated at 1.34 billion £. Direct costs represented 28%, informal care accounted for 26% and indirect costs amounted to 46%. Of the direct costs, an estimated £ per patient or % of total costs are paid for by the NHS. Intangible costs were estimated at 5000 £ per patient and year. The mean age of the cohort was 44 years (disease onset 34), the mean utility measured with EQ-5D was 0.487 (0.919 to -0.594), and the mean EDSS score 5.1 (1.0 to 9.5). All costs (direct, informal care, indirect) increased with increasing EDSS scores, while utilities decreased.

Sprache
Englisch

Erschienen in
Series: SSE/EFI Working Paper Series in Economics and Finance ; No. 398

Klassifikation
Wirtschaft
Allocative Efficiency; Cost-Benefit Analysis
Publicly Provided Private Goods
National Government Expenditures and Health
Social Security and Public Pensions
Health: Government Policy; Regulation; Public Health
Thema
multiple sclerosis
cost-of-illness
quality of life
EDSS
utility
Krankheit
Kosten
Lebensqualität
Statistischer Test
Deutschland

Ereignis
Geistige Schöpfung
(wer)
Kobelt, Gisela
Lindgren, Peter
Parkin, David
Francis, David A.
Johnson, Michael
Bates, David
Jönsson, Bengt
Ereignis
Veröffentlichung
(wer)
Stockholm School of Economics, The Economic Research Institute (EFI)
(wo)
Stockholm
(wann)
2000

Handle
Letzte Aktualisierung
10.03.2025, 11:42 MEZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften - Leibniz-Informationszentrum Wirtschaft. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.

Objekttyp

  • Arbeitspapier

Beteiligte

  • Kobelt, Gisela
  • Lindgren, Peter
  • Parkin, David
  • Francis, David A.
  • Johnson, Michael
  • Bates, David
  • Jönsson, Bengt
  • Stockholm School of Economics, The Economic Research Institute (EFI)

Entstanden

  • 2000

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