Leveraging Electron‐Deficient Iminium Intermediates in a General Synthesis of Valuable Amines
Abstract: The development of reactions converting alkenes and alkynes into valuable building blocks remains one of the main goals of synthetic chemistry. Herein, we present the leveraging of highly electron‐deficient iminium ions, rare and fleeting intermediates, into a general amine synthesis. This enables the preparation of amines bearing e.g. valuable α‐trifluoromethyl moieties under mild conditions. This broad concept is highlighted by the late‐stage amination of quinine into a biologically interesting new analogue.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Leveraging Electron‐Deficient Iminium Intermediates in a General Synthesis of Valuable Amines ; day:16 ; month:03 ; year:2022 ; extent:1
Angewandte Chemie / International edition. International edition ; (16.03.2022) (gesamt 1)
- Creator
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Hsu, Che‐Sheng
Gonçalves, Carlos R.
Tona, Veronica
Pons, Amandine
Kaiser, Marcel
Maulide, Nuno
- DOI
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10.1002/anie.202115435
- URN
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urn:nbn:de:101:1-2022032514394065699692
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:32 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hsu, Che‐Sheng
- Gonçalves, Carlos R.
- Tona, Veronica
- Pons, Amandine
- Kaiser, Marcel
- Maulide, Nuno
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