EGR3 Inhibits Tumor Progression by Inducing Schwann Cell‐Like Differentiation
Abstract: The mechanism and function of the expression of Schwann characteristics by nevus cells in the mature zone of the dermis are unknown. Early growth response 3 (EGR3) induces Schwann cell‐like differentiation of melanoma cells by simulating the process of nevus maturation, which leads to a strong phenotypic transformation of the cells, including the formation of long protrusions and a decrease in cell motility, proliferation, and melanin production. Meanwhile, EGR3 regulates the levels of myelin protein zero (MPZ) and collagen type I alpha 1 chain (COL1A1) through SRY‐box transcription factor 10 (SOX10)‐dependent and independent mechanisms, by binding to non‐strictly conserved motifs, respectively. Schwann cell‐like differentiation demonstrates significant benefits in both in vivo and clinical studies. Finally, a CD86‐P2A‐EGR3 recombinant mRNA vaccine is developed which leads to tumor control through forced cell differentiation and enhanced immune infiltration. Together, these data support further development of the recombinant mRNA as a treatment for cancer.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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EGR3 Inhibits Tumor Progression by Inducing Schwann Cell‐Like Differentiation ; day:07 ; month:07 ; year:2024 ; extent:18
Advanced science ; (07.07.2024) (gesamt 18)
- Urheber
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Chen, Cai‐hong
Chen, Yang
Li, Yi‐nan
Zhang, Heng
Huang, Xiu
Li, Ying‐ying
Li, Zhi‐yang
Han, Jing‐xia
Wu, Xin‐ying
Liu, Hui‐juan
Sun, Tao
- DOI
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10.1002/advs.202400066
- URN
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urn:nbn:de:101:1-2407091433105.713333301628
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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21.03.0008, 08:01 MEZ
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Beteiligte
- Chen, Cai‐hong
- Chen, Yang
- Li, Yi‐nan
- Zhang, Heng
- Huang, Xiu
- Li, Ying‐ying
- Li, Zhi‐yang
- Han, Jing‐xia
- Wu, Xin‐ying
- Liu, Hui‐juan
- Sun, Tao
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