Overexpression of KMT9α is associated with aggressive basal-like muscle-invasive bladder cancer

to related objects

Abstract: Muscle-invasive bladder cancer (MIBC) is associated with limited response rates to systemic therapy leading to a significant risk of recurrence and death. A recently discovered histone methyltransferase KMT9, acts as an epigenetic regulator of carcinogenesis in different tumor entities. In this study, we investigated the presence and association of histological and molecular subtypes and their impact on the survival of KMT9α in MIBC. We performed an immunohistochemical (IHC) analysis of KMT9α in 135 MIBC patients undergoing radical cystectomy. KMT9α was significantly overexpressed in the nucleus in MIBC compared to normal urothelium and low-grade urothelial cancer. Using the HTG transcriptome panel, we assessed mRNA expression profiles to determine molecular subtypes and identify differentially expressed genes. Patients with higher nuclear and nucleolar KMT9α expression showed basal/squamous urothelial cancer characteristics confirmed by IHC and differentially upregulated KRT14 expression. We identified a subset of patients with nucleolar expression of KMT9α, which was associated with an increased risk of death in uni- and multivariate analyses (HR 2.28, 95%CI 1.28–4.03, p = 0.005). In conclusion, basal-like MIBC and the squamous histological subtype are associated with high nuclear KMT9α expression. The association with poor survival makes it a potential target for the treatment of bladder cancer

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
Cells. - 12, 4 (2023) , 589, ISSN: 2073-4409

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2023
Creator

DOI
10.3390/cells12040589
URN
urn:nbn:de:bsz:25-freidok-2362651
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
14.08.2025, 10:53 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Show original at data provider

Associated

Time of origin

  • 2023

Other Objects (12)

Prostate cancer: active surveillance, diagnostic modalities and biopsy in the management of prostate cancer

Aufsatzsammlung

Prostate cancer: active surveillance, diagnostic modalities and biopsy in the management of prostate cancer

Evaluation eines Clinical Decision Support System zur Unterstützung eines möglichst evidenzbasierten perioperativen Managements von antikoagulierten Patienten

Evaluation eines Clinical Decision Support System zur Unterstützung eines möglichst evidenzbasierten perioperativen Managements von antikoagulierten Patienten

Retrospektive Analyse des Outcomes von Patienten nach Ileostomarückverlagerung in Abhängigkeit vom Ausbildungsstand des Operateurs

Retrospektive Analyse des Outcomes von Patienten nach Ileostomarückverlagerung in Abhängigkeit vom Ausbildungsstand des Operateurs

Hinmans Atlas der urologischen Chirurgie

Atlas

Hinmans Atlas der urologischen Chirurgie

Hämatologische Sicherheit der 177Lu-PSMA-617 Radioligandentherapie bei Patienten mit metastasiertem kastrationsresistentem Prostatakarzinom

Hämatologische Sicherheit der 177Lu-PSMA-617 Radioligandentherapie bei Patienten mit metastasiertem kastrationsresistentem Prostatakarzinom

Editorial: Education in genitourinary surgery 2022

Editorial: Education in genitourinary surgery 2022

Sulforaphane impact on reactive oxygen species (ROS) in bladder carcinoma

Sulforaphane impact on reactive oxygen species (ROS) in bladder carcinoma

Wertigkeit der CD4-Zellzahlbestimmung in Diagnostik und Therapie von Harnwegsinfektionen und Urosepsis nach Nierentransplantation

Wertigkeit der CD4-Zellzahlbestimmung in Diagnostik und Therapie von Harnwegsinfektionen und Urosepsis nach Nierentransplantation

Diagnosis of clinically significant prostate cancer diagnosis without histological proof in the prostate-specific membrane antigen era: the jury is still out

Diagnosis of clinically significant prostate cancer diagnosis without histological proof in the prostate-specific membrane antigen era: the jury is still out

Feline mammary basal-like adenocarcinomas: a potential model for human triple-negative breast cancer (TNBC) with basal-like subtype

Feline mammary basal-like adenocarcinomas: a potential model for human triple-negative breast cancer (TNBC) with basal-like subtype

Sulforaphane reduces prostate cancer cell growth and proliferation in vitro by modulating the Cdk-Cyclin axis and expression of the CD44 variants 4, 5, and 7

Sulforaphane reduces prostate cancer cell growth and proliferation in vitro by modulating the Cdk-Cyclin axis and expression of the CD44 variants 4, 5, and 7

Prospektive Evaluation von E-Learning Optionen im Fach Anästhesiologie durch öffentlich verfügbares Videomaterial in YouTube

Prospektive Evaluation von E-Learning Optionen im Fach Anästhesiologie durch öffentlich verfügbares Videomaterial in YouTube

Related objects