Recurrent respiratory tract infections (RRTI) in the elderly: a late onset mild immunodeficiency?

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Abstract: Elderly with late-onset recurrent respiratory tract infections (RRTI) often have specific anti-polysaccharide antibody deficiency (SPAD). We hypothesized that late-onset RRTI is caused by mild immunodeficiencies, such as SPAD, that remain hidden through adult life. We analyzed seventeen elderly RRTI patients and matched controls. We determined lymphocyte subsets, expression of BAFF receptors, serum immunoglobulins, complement pathways, Pneumovax-23 vaccination response and genetic variations in BAFFR and MBL2. Twelve patients (71%) and ten controls (59%) had SPAD. IgA was lower in patients than in controls, but other parameters did not differ. However, a high percentage of both patients (53%) and controls (65%) were MBL deficient, much more than in the general population. Often, MBL2 secretor genotypes did not match functional deficiency, suggesting that functional MBL deficiency can be an acquired condition. In conclusion, we found SPAD and MBL deficiency in many elderly, and conjecture that at least the latter arises with age

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: Clinical immunology. - 180 (2017) , 111-119, ISSN: 1521-7035

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2023

Creator: Vosse, Esther van der
Ostaijen-ten Dam, Monique M. van
Vermaire, René
Verhard, Els M.
Waaijer, Jacqueline L.
Bakker, Jaap A.
Bernards, Sandra T.
Eibel, Hermann
Tol, Maarten J. van
Dissel, Jaap T. van
Haverkamp, Margje H.

DOI: 10.1016/j.clim.2017.05.008

URN: urn:nbn:de:bsz:25-freidok-1424068

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 25.03.2025, 1:50 PM CET

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Associated

Vosse, Esther van der
Ostaijen-ten Dam, Monique M. van
Vermaire, René
Verhard, Els M.
Waaijer, Jacqueline L.
Bakker, Jaap A.
Bernards, Sandra T.
Eibel, Hermann
Tol, Maarten J. van
Dissel, Jaap T. van
Haverkamp, Margje H.
Universität

Time of origin

2023

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Recurrent respiratory tract infections (RRTI) in the elderly: a late onset mild immunodeficiency?

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