Polygenic Score for Conscientiousness Is a Protective Factor for Reversion from Mild Cognitive Impairment to Normal Cognition
Abstract: Spontaneous reversion from mild cognitive impairment (MCI) to normal cognition (NC) is little known. Based on the data of the Genetics of Personality Consortium and MCI participants from Alzheimer's Disease Neuroimaging Initiative, the authors investigate the effect of polygenic scores (PGS) for personality traits on the reversion of MCI to NC and its underlying neurobiology. PGS analysis reveals that PGS for conscientiousness (PGS‐C) is a protective factor that supports the reversion from MCI to NC. Gene ontology enrichment analysis and tissue‐specific enrichment analysis indicate that the protective effect of PGS‐C may be attributed to affecting the glutamatergic synapses of subcortical structures, such as hippocampus, amygdala, nucleus accumbens, and caudate nucleus. The structural covariance network (SCN) analysis suggests that the left whole hippocampus and its subfields, and the left whole amygdala and its subnuclei show significantly stronger covariance with several high‐cognition relevant brain regions in the MCI reverters compared to the stable MCI participants, which may help illustrate the underlying neural mechanism of the protective effect of PGS‐C.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Polygenic Score for Conscientiousness Is a Protective Factor for Reversion from Mild Cognitive Impairment to Normal Cognition ; day:05 ; month:06 ; year:2024 ; extent:12
Advanced science ; (05.06.2024) (gesamt 12)
- Creator
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Yang, Xuan
Wang, Zirui
Li, Haonan
Qin, Wen
Liu, Nana
Liu, Zhixuan
Wang, Siqi
Xu, Jiayuan
Wang, Junping
- DOI
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10.1002/advs.202309889
- URN
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urn:nbn:de:101:1-2406061403071.716073126592
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:59 AM CEST
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Yang, Xuan
- Wang, Zirui
- Li, Haonan
- Qin, Wen
- Liu, Nana
- Liu, Zhixuan
- Wang, Siqi
- Xu, Jiayuan
- Wang, Junping
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