Skin‐Interfaced Bifluidic Paper‐Based Device for Quantitative Sweat Analysis
Abstract: The erratic, intermittent, and unpredictable nature of sweat production, resulting from physiological or psychological fluctuations, poses intricacies to consistently and accurately sample and evaluate sweat biomarkers. Skin‐interfaced microfluidic devices that rely on colorimetric mechanisms for semi‐quantitative detection are particularly susceptible to these inaccuracies due to variations in sweat secretion rate or instantaneous volume. This work introduces a skin‐interfaced colorimetric bifluidic sweat device with two synchronous channels to quantify sweat rate and biomarkers in real‐time, even during uncertain sweat activities. In the proposed bifluidic‐distance metric approach, with one channel to measure sweat rate and quantify collected sweat volume, the other channel can provide an accurate analysis of the biomarkers based on the collected sweat volume. The closed channel design also reduces evaporation and resists contamination from the external environment. The feasibility of the device is highlighted in a proof‐of‐the‐concept demonstration to analyze sweat chloride for evaluating hydration status and sweat glucose for assessing glucose levels. The low‐cost yet highly accurate device provides opportunities for clinical sweat analysis and disease screening in remote and low‐resource settings. The developed device platform can be facilely adapted for the other biomarkers when corresponding colorimetric reagents are exploited.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Skin‐Interfaced Bifluidic Paper‐Based Device for Quantitative Sweat Analysis ; day:22 ; month:12 ; year:2023 ; extent:11
Advanced science ; (22.12.2023) (gesamt 11)
- Creator
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Deng, Muhan
Li, Xiaofeng
Song, Kui
Yang, Hanlin
Wei, Wenkui
Duan, Xiaojun
Ouyang, Xiaoping
Cheng, Huanyu
Wang, Xiufeng
- DOI
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10.1002/advs.202306023
- URN
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urn:nbn:de:101:1-2023122314073160274492
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:39 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Deng, Muhan
- Li, Xiaofeng
- Song, Kui
- Yang, Hanlin
- Wei, Wenkui
- Duan, Xiaojun
- Ouyang, Xiaoping
- Cheng, Huanyu
- Wang, Xiufeng
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