No evidence for an association of voxel-based morphometry with short-term non-motor outcomes in deep brain stimulation for Parkinson’s disease

Abstract: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established therapy in advanced Parkinson’s disease (PD). Motor and non-motor outcomes, however, show considerable inter-individual variability. Preoperative morphometry-based metrics have recently received increasing attention to explain treatment effects. As evidence for the prediction of non-motor outcomes is limited, we sought to investigate the association between metrics of voxel-based morphometry and short-term non-motor outcomes following STN-DBS in this prospective open-label study. Forty-nine PD patients underwent structural MRI and a comprehensive clinical assessment at preoperative baseline and 6-month follow-up. Voxel-based morphometry was used to assess associations between cerebral volume and non-motor outcomes corrected for multiple comparisons using a permutation-based approach. We replicated existing results associating volume loss of the superior frontal cortex with subpar motor outcomes. Overall non-motor burden, however, was not significantly associated with morphometric features, limiting its use as a marker to inform patient selection and holistic preoperative counselling

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: npj Parkinson's Disease. - 10, 1 (2024) , 91, ISSN: 2373-8057

Klassifikation und Themen

• Klassifikation: Medizin, Gesundheit

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2024
• Urheber: Loehrer, Philipp Alexander ; Schumacher, Wibke ; Jost, Stefanie T. ; Silverdale, Monty ; Petry-Schmelzer, Jan Niklas ; Sauerbier, Anna ; Gronostay, Alexandra ; Visser-Vandewalle, Veerle ; Fink, Gereon R. ; Evans, Julian ; Krause, Max ; Rizos, Alexandra ; Antonini, Angelo ; Ashkan, Keyoumars ; Martinez-Martin, Pablo ; Gaser, Christian ; Chaudhuri, K. Ray ; Timmermann, Lars ; Baldermann, Juan Carlos ; Dafsari, Haidar Salimi

Weitere Informationen

• DOI: 10.1038/s41531-024-00695-1
• URN: urn:nbn:de:bsz:25-freidok-2494454
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:57 MESZ