NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2

to related objects

Abstract: Postoperative cognitive dysfunction (POCD) is a common complication of cognitive decline after surgery and anesthesia. Sevoflurane, as a commonly used anesthetic, was found to cause POCD. Nudix Hydrolase 21 (NUDT21), a conserved splicing factor, has been reported to exert important functions in multiple diseases’ progression. In this study, the effect of NUDT21 on sevoflurane-induced POCD was elucidated. Results showed that NUDT21 was down-regulated in the hippocampal tissue of sevoflurane-induced rats. Morris water maze test results revealed that overexpression of NUDT21 improved sevoflurane-induced cognitive impairment. In addition, TUNEL assay results indicated that enhanced NUDT21 alleviated sevoflurane-induced apoptosis of hippocampal neurons. Furthermore, overexpression of NUDT21 suppressed the sevoflurane-induced LIMK2 expression. Taken together, NUDT21 alleviates sevoflurane-induced neurological damage in rats by down-regulating LIMK2, providing a novel target for the prevention of sevoflurane-induced POCD.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2 ; volume:18 ; number:1 ; year:2023 ; extent:8
Open life sciences ; 18, Heft 1 (2023) (gesamt 8)

Creator: Zhong, Yuanping
Zhao, Pengcheng
Zhang, Chao
Wu, Zhenyu
Fang, Xu
Zhu, Zhaoqiong

DOI: 10.1515/biol-2022-0486

URN: urn:nbn:de:101:1-2023041514031330888019

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:59 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Zhong, Yuanping
Zhao, Pengcheng
Zhang, Chao
Wu, Zhenyu
Fang, Xu
Zhu, Zhaoqiong

Other Objects (12)

Yu chu xin zhi. [1], Ch. 1-10 : 10 ce

Yu chu xin zhi. [2], Ch. 11-20 : 10 ce

Reliability of steel columns protected by intumescent coatings subjected to natural fires

Yu chu xin zhi

Noncoercive resonant (p, 2)-equations with concave terms

Equivalence between distributional and viscosity solutions for the double-phase equation

Semantic connection set-based massive RDF data query processing in Spark environment

Classification and criteria of limit cases for singular second-order linear equations with complex coefficients on time scales

Holistic evaluation in multi-model databases benchmarking

$Existence of positive solutions to elliptic problems involving the fractional Laplacian$

Existence of positive solutions to elliptic problems involving the fractional Laplacian

Double phase anisotropic variational problems involving critical growth

Correction to: Comparison of hypoxemia, intubation procedure, and complications for noninvasive ventilation against high-flow nasal cannula oxygen therapy for patients with acute hypoxemic respiratory failure: a nonrandomized retrospective analysis for effectiveness and safety (NIVaHIC-aHRF)

Yu chu xin zhi. [1], Ch. 1-10 : 10 ce

Yu chu xin zhi. [2], Ch. 11-20 : 10 ce

Reliability of steel columns protected by intumescent coatings subjected to natural fires

Yu chu xin zhi

Noncoercive resonant (p, 2)-equations with concave terms

Equivalence between distributional and viscosity solutions for the double-phase equation

Semantic connection set-based massive RDF data query processing in Spark environment

Classification and criteria of limit cases for singular second-order linear equations with complex coefficients on time scales

Holistic evaluation in multi-model databases benchmarking

$Existence of positive solutions to elliptic problems involving the fractional Laplacian$

Existence of positive solutions to elliptic problems involving the fractional Laplacian

Double phase anisotropic variational problems involving critical growth

Correction to: Comparison of hypoxemia, intubation procedure, and complications for noninvasive ventilation against high-flow nasal cannula oxygen therapy for patients with acute hypoxemic respiratory failure: a nonrandomized retrospective analysis for effectiveness and safety (NIVaHIC-aHRF)

Yu chu xin zhi. [1], Ch. 1-10 : 10 ce

Yu chu xin zhi. [2], Ch. 11-20 : 10 ce

Reliability of steel columns protected by intumescent coatings subjected to natural fires

Yu chu xin zhi

Noncoercive resonant (p, 2)-equations with concave terms

Equivalence between distributional and viscosity solutions for the double-phase equation

Semantic connection set-based massive RDF data query processing in Spark environment

Classification and criteria of limit cases for singular second-order linear equations with complex coefficients on time scales

Holistic evaluation in multi-model databases benchmarking

$Existence of positive solutions to elliptic problems involving the fractional Laplacian$

Existence of positive solutions to elliptic problems involving the fractional Laplacian

Double phase anisotropic variational problems involving critical growth

Correction to: Comparison of hypoxemia, intubation procedure, and complications for noninvasive ventilation against high-flow nasal cannula oxygen therapy for patients with acute hypoxemic respiratory failure: a nonrandomized retrospective analysis for effectiveness and safety (NIVaHIC-aHRF)

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.

NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2

Object Details

References and Relationships

Contributors, Places and Time

Further information

Data provider

Associated

Other Objects (12)

Yu chu xin zhi. [1], Ch. 1-10 : 10 ce

Yu chu xin zhi. [2], Ch. 11-20 : 10 ce

Reliability of steel columns protected by intumescent coatings subjected to natural fires

Yu chu xin zhi

Noncoercive resonant (p, 2)-equations with concave terms

Equivalence between distributional and viscosity solutions for the double-phase equation

Semantic connection set-based massive RDF data query processing in Spark environment

Classification and criteria of limit cases for singular second-order linear equations with complex coefficients on time scales

Holistic evaluation in multi-model databases benchmarking

Existence of positive solutions to elliptic problems involving the fractional Laplacian

Double phase anisotropic variational problems involving critical growth

Correction to: Comparison of hypoxemia, intubation procedure, and complications for noninvasive ventilation against high-flow nasal cannula oxygen therapy for patients with acute hypoxemic respiratory failure: a nonrandomized retrospective analysis for effectiveness and safety (NIVaHIC-aHRF)

Yu chu xin zhi. [1], Ch. 1-10 : 10 ce

Yu chu xin zhi. [2], Ch. 11-20 : 10 ce

Reliability of steel columns protected by intumescent coatings subjected to natural fires

Yu chu xin zhi

Noncoercive resonant (p, 2)-equations with concave terms

Equivalence between distributional and viscosity solutions for the double-phase equation

Semantic connection set-based massive RDF data query processing in Spark environment

Classification and criteria of limit cases for singular second-order linear equations with complex coefficients on time scales

Holistic evaluation in multi-model databases benchmarking

Existence of positive solutions to elliptic problems involving the fractional Laplacian

Double phase anisotropic variational problems involving critical growth

Correction to: Comparison of hypoxemia, intubation procedure, and complications for noninvasive ventilation against high-flow nasal cannula oxygen therapy for patients with acute hypoxemic respiratory failure: a nonrandomized retrospective analysis for effectiveness and safety (NIVaHIC-aHRF)

Yu chu xin zhi. [1], Ch. 1-10 : 10 ce

Yu chu xin zhi. [2], Ch. 11-20 : 10 ce

Reliability of steel columns protected by intumescent coatings subjected to natural fires

Yu chu xin zhi

Noncoercive resonant (p, 2)-equations with concave terms

Equivalence between distributional and viscosity solutions for the double-phase equation

Semantic connection set-based massive RDF data query processing in Spark environment

Classification and criteria of limit cases for singular second-order linear equations with complex coefficients on time scales

Holistic evaluation in multi-model databases benchmarking

Existence of positive solutions to elliptic problems involving the fractional Laplacian

Double phase anisotropic variational problems involving critical growth

Correction to: Comparison of hypoxemia, intubation procedure, and complications for noninvasive ventilation against high-flow nasal cannula oxygen therapy for patients with acute hypoxemic respiratory failure: a nonrandomized retrospective analysis for effectiveness and safety (NIVaHIC-aHRF)

Related objects

Reset password