Does asthma affect the risk of developing breast cancer?
Abstract: Background
The role of the immune system in cancer defense is likely underappreciated. While there has been longstanding interest in the role of atopic diseases in cancer, only a few studies have tested this hypothesis.
Methods
We analyzed data from 202,055 women participating in the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHS II) to explore whether asthma is associated with breast cancer. We used Cox proportional hazards models to link physician-diagnosed asthma with subsequent incidence of breast cancer.
Results
Across the two cohorts, we identified 18,403 cases of physician-diagnosed asthma. During 4,393,760 person-years of follow-up, 11,096 incident cases of breast cancer were diagnosed. In NHS, women with asthma had a covariate-adjusted hazard ratio of 0.92 (95% CI: 0.86–0.99) to develop breast cancer compared to women without asthma; the respective HR in NHS II was 0.93 (0.84–1.03), and 0.92 (0.87–0.98) in the pooled analysis. Among never-smokers, the HR for breast cancer was 0.91 (0.81–1.02) in NHS, 0.81 (0.70–0.93) in NHS II, and 0.86 (0.77–0.97) combined. In two large prospective cohorts of women, participants with asthma had a somewhat lower risk of breast cancer. An active immune system may provide protection from breast cancer.
Conclusions
In these longitudinal studies, women with asthma had a somewhat lower risk of breast cancer. This association was most pronounced among never smokers. An active immune system may provide protection from breast cancer
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Cancer medicine. - 14, 1 (2025) , e70539, ISSN: 2045-7634
- Event
-
Veröffentlichung
- (where)
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Freiburg
- (who)
-
Universität
- (when)
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2025
- Creator
- DOI
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10.1002/cam4.70539
- URN
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urn:nbn:de:bsz:25-freidok-2624143
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 15.08.2025, 7:29 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Michels, Karin
- Dumas, Orianne
- Varraso, Raphaelle
- Villari, Antonio Carlos Camargo
- Universität
Time of origin
- 2025
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