Role of ABO blood group in SARS-CoV-2 infection in households

Abstract: An association between certain ABO/Rh blood groups and susceptibility to SARS-CoV-2 infection has been proposed for adults, although this remains controversial. In children and adolescents, the relationship is unclear due to a lack of robust data. Here, we investigated the association of ABO/Rh blood groups and SARS-CoV-2 in a multi-center study comprising 163 households with 281 children and 355 adults and at least one SARS-CoV-2 seropositive individual as determined by three independent assays as a proxy for previous infection. In line with previous findings, we found a higher frequency of blood group A (+ 6%) and a lower frequency of blood group O (−6%) among the SARS-CoV-2 seropositive adults compared to the seronegative ones. This trend was not seen in children. In contrast, SARS-CoV-2 seropositive children had a significantly lower frequency of Rh-positive blood groups. ABO compatibility did not seem to play a role in SARS-CoV-2 transmission within the families. A correction for family clusters was performed and estimated fixed effects of the blood group on the risk of SARS-CoV-2 seropositivity and symptomatic infection were determined. Although we found a different distribution of blood groups in seropositive individuals compared to the reference population, the risk of SARS-CoV-2 seropositivity or symptomatic infection was not increased in children or in adults with blood group A or AB versus O or B. Increasing age was the only parameter positively correlating with the risk of SARS-CoV-2 infection. In conclusion, specific ABO/Rh blood groups and ABO compatibility appear not to predispose for SARS-CoV-2 susceptibility in children

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Frontiers in microbiology. - 13 (2022) , 857965, ISSN: 1664-302X

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2022
• Urheber: Janda, Ales̆ ; Engel, Corinna ; Remppis, Jonathan ; Enkel, Sigrid ; Peter, Andreas ; Hörber, Sebastian ; Ganzenmueller, Tina ; Schober, Sarah ; Weinstock, Christof ; Jacobsen, Eva-Maria ; Fabricius, Dorit ; Zernickel, Maria ; Stamminger, Thomas ; Dietz, Andrea ; Groß, Hans-Jürgen ; Bode, Sebastian Felix Nepomuk ; Haddad, Anneke ; Elling, Roland ; Stich, Maximilian ; Tönshoff, Burkhard ; Henneke, Philipp ; Debatin, Klaus-Michael ; Franz, Axel R. ; Renk, Hanna

Weitere Informationen

• DOI: 10.3389/fmicb.2022.857965
• URN: urn:nbn:de:bsz:25-freidok-2270361
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:28 MESZ